奥曲肽联合生长抑素治疗肝硬化上消化道出血的临床效果  

Clinical effect of octreotide combined with somatostatin in the treatment of upper gastrointestinal hemorrhage due to liver cirrhosis

作　　者：刘芝德 LIU Zhi-de(Shenyang Sujiatun District Central Hospital,Shenyang 110101,China)

机构地区：[1]沈阳市苏家屯区中心医院

出　　处：《中国现代药物应用》2020年第1期105-107,共3页Chinese Journal of Modern Drug Application

摘　　要：目的 探究奥曲肽联合生长抑素治疗肝硬化上消化道出血的临床效果。方法 78例肝硬化上消化道出血患者,按照随机数字表法分为参照组和研究组,各39例。两组患者均进行止血、输血等常规抗休克治疗,在此基础上,参照组使用奥曲肽治疗,研究组则在参照组基础上增加生长抑素。比较两组的治疗效果、止血时间、输血量及不良反应发生情况。结果 研究组总有效率94.87%(37/39)高于参照组的79.49%(31/39),差异具有统计学意义(P<0.05)。研究组止血时间(23.37±4.19)h,输血量(2.55±0.62)U均优于参照组的(28.26±5.63)h、(3.25±0.79)U,差异均有统计学意义(P<0.05)。研究组不良反应发生率7.69%(3/39)低于参照组的25.64%(10/39),差异具有统计学意义(P<0.05)。结论 对肝硬化上消化道出血患者使用奥曲肽联合生长抑素治疗疗效显著,且安全性高,值得临床推广。Objective To investigate the clinical effect of octreotide combined with somatostatin in the treatment of upper gastrointestinal hemorrhage due to liver cirrhosis.Methods A total of 78 cases of upper gastrointestinal hemorrhage due to liver cirrhosis were divided into control group and research group by random number table method,with 39 cases in each group.Both groups received routine antishock therapy of hemostasis and blood transfusion.On this basis,the control group was treated by octreotide,and the research group was treated by somatostatin on the basis of the control group.The therapeutic effect,hemostasis time,amount of blood transfusion and occurrence of adverse reactions was compared between the two groups.Results The total effective rate 94.87% (37/39)in the research group was higher than 79.49% (31/39)in the control group,and the difference was statistically significant(P<0.05).The hemostasis time,amount of blood transfusion were(23.37±4.19)h and(2.55±0.62)U in the research group,which was better than(28.26±5.63)h and(3.25±0.79)U in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 7.69% (3/39)in the research group was lower than 25.64% (10/39)in the control group,and the difference was statistically significant(P<0.05).Conclusion Octreotide combined with somatostatin shows remarkable efficacy in the treatment of patients with upper gastrointestinal hemorrhage due to liver cirrhosis with high safety,and it is worthy of clinical promotion.

关 键 词：奥曲肽 生长抑素 肝硬化 上消化道出血 治疗效果 

分 类 号：R575.2[医药卫生—消化系统] R573.2[医药卫生—内科学]