尿酸排泄分数与脑梗死关系的临床研究  

Clinical study on the relationship between uric acid excretion fraction and cerebral infarction

作　　者：孟可 吴苗苗 文芮 闵连秋 MENG Ke;WU Miaomiao;WEN Rui(Department of Neurology,The First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121000,China)

机构地区：[1]锦州医科大学附属第一医院神经内科,辽宁锦州121000 [2]贵州医科大学附属医院神经内科,贵州贵阳550000

出　　处：《中风与神经疾病杂志》2019年第12期1109-1112,共4页Journal of Apoplexy and Nervous Diseases

基　　金：辽宁省自然科学基金指导计划项目(No.20170540379)

摘　　要：目的探讨尿酸排泄分数(fraction excretion of uric acid,FEUA)与脑梗死(cerebral infarction,CI)之间的关系。方法收集2016年12月-2018年12月在锦州医科大学附属第一医院神经内科住院治疗的发病48 h内的CI患者为研究组,选取同期我院体检中心健康体检者为对照组;研究组患者均于入院时进行NIHSS评分,根据评分结果将病情分为轻度和重度;测定两组的生化全项、空腹血清及12 h尿中尿酸和肌酐浓度,计算出FEUA并分析FEUA在两组间及研究组内的差异。结果空腹血糖、同型半胱氨酸、体重指数及FEUA为脑梗死发病独立危险因素。与对照组相比,研究组患者的血尿酸水平明显高于对照组,FEUA明显降低,差异具有显著性(P<0.05);同时发现FEUA与脑梗死患者的病情严重程度密切相关,病情重者的FEUA明显低于病情轻者,差异具有显著性(P<0.05)。结论FEUA与脑梗死的发生及病情严重程度相关。Objective To investigate the relationship between uric acid excretion fraction and cerebral infarction.Methods CI patients hospitalized in the department of neurology of the first affiliated hospital of Jinzhou medical University within 48 hours from December 2016 to 2018 were collected as the study group,and healthy subjects in the physical examination center of our hospital during the same period were selected as the control group.All patients in the study group received NIHSS score upon admission,and their conditions were classified as mild and severe according to the score results.The biochemical whole term,fasting serum and the concentration of uric acid and creatinine in 12 h urine of the two groups were determined.FEUA was calculated and the difference of FEUA between the two group and in the study group were analyzed.Results Fasting blood glucose,homocysteine,body mass index and FEUA were independent risk factors for cerebral infarction.Compared with the control group,serum uric acid level in the study group was significantly higher than that in the control group,and FEUA level was significantly lower in the study group(P<0.05).At the same time,FEUA was found to be closely related to the severity of cerebral infarction,and FEUA was significantly lower in patients with severe cerebral infarction than in patients with mild cerebral infarction(P<0.05).Conclusion FEUA was associated with the occurrence and severity of cerebral infarction.

关 键 词：尿酸 尿酸排泄分数 脑梗死 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]