环孢素A联合糖皮质激素治疗蚕食性角膜溃疡的疗效  

Effect of cyclosporine A combined with glucocorticoid in the treatment of corneal ulcer

作　　者：张桐[1] 祝天辉 林宝涛[1] Tong Zhang;Tian-Hui Zhu;Bao-Tao Lin(Shenzhen Ophthalmological Hospital,Shenzhen 518034,Guangdong Province,China)

机构地区：[1]中国广东省深圳市眼科医院

出　　处：《国际眼科杂志》2020年第2期286-289,共4页International Eye Science

基　　金：广东省医学科学技术研究基金项目(No.B2019006)~~

摘　　要：目的:研究环孢素A联合糖皮质激素对蚕食性角膜溃疡的疗效。方法:选取2015-05/2018-05在我院就诊的蚕食性角膜溃疡患者200例,根据治疗方式的不同分为联合组和糖皮质激素组,各100例。糖皮质激素组给予糖皮质激素进行治疗,联合组在糖皮质激素组的基础上给予环孢素A治疗。检测患者C反应蛋白(CRP)、白介素-6(IL-6)水平,评估生存质量,检查临床症状,比较两组治疗有效率、复发率、不良反应发生率。结果:两组治疗后CRP、IL-6水平低于治疗前,生存质量高于治疗前(P<0.05)。联合组治疗后CRP、IL-6水平低于糖皮质激素组治疗后,生存质量高于糖皮质激素组治疗后(P<0.05)。联合组结膜充血消退时间、眼痛消失时间、溃疡愈合时间低于糖皮质激素组(P<0.05)。联合组治疗有效率高于糖皮质激素组,复发率低于糖皮质激素组(P<0.05)。结论:环孢素A联合激素治疗蚕食性角膜溃疡效果显著,能改善患者临床症状,降低炎症反应,提高患者生活质量,降低复发。·AIM:To study the effect of cyclosporine A combined with glucocorticoid in the treatment of corneal ulcer.·METHODS:From May 2015 to May 2018,200 patients with corneal ulcer were selected and divided into combined group and glucocorticoid group according to different treatment methods,100 cases each.In the combined group,cyclosporine A was given on the basis of the glucocorticoid group.C-reactive protein(CRP) and interleukin-6(IL-6) were measured to evaluate the quality of life,clinical symptoms,treatment efficiency,recurrence rate and incidence of adverse reactions.·RESULTS:After treatment,the levels of CRP and IL-6 in the two groups were lower than that before treatment,and the quality of life was higher than that before treatment(P<0.05).The level of CRP and IL-6 in the combined group was lower than that in the glucocorticoid group,and the quality of life was higher than that in the glucocorticoid group(P<0.05).The time of conjunctival hyperemia,ophthalmalgia and ulcer healing in the combined group were lower than those in the glucocorticoid group(P <0.05).The effective rate of combined group was higher than that of glucocorticoid group,and the recurrence rate of combined group was lower than that of glucocorticoid group(P<0.05).·CONCLUSION:Cyclosporine a combined with hormone is effective in the treatment of corneal ulcer,which can improve the clinical symptoms,reduce the inflammation,improve the quality of life and reduce the recurrence.

关 键 词：环孢素A 糖皮质激素 蚕食性角膜溃疡 复发 

分 类 号：R772.2[医药卫生—眼科]