软性接触镜和rb-bFGF滴眼液对角膜深层异物剔除术后促修复的疗效比较  

Comparison of the effect of soft contact lens and rb-bFGF eye drops on promoting postoperative repair of deep corneal foreign body

作　　者：吴晓玉 李成茂 王灿林 Xiao-Yu Wu;Cheng-Mao Li;Can-Lin Wang(Department of Ophthalmology,the 910 th Hospital of Chinese People's Liberation Army,Quanzhou 362000,Fujian Province,China)

机构地区：[1]中国人民解放军联勤保障部队第九一○医院眼科

出　　处：《国际眼科杂志》2020年第2期332-335,共4页International Eye Science

摘　　要：目的:分析软性接触镜(SCL)和rb-bFGF滴眼液在角膜深层异物剔除术后促修复能力的情况。方法:将我院2017-01-01/2019-04-30角膜深层异物患者72例72眼随机分为三组,除每例术后均予左氧氟沙星滴眼液和氧氟沙星眼膏预防感染治疗外,A组术后配戴SCL,简称戴镜组;B组术后局部使用rb-bFGF滴眼液,简称rb-bFGF组;C组为空白组。比较三组患者术后1、3、5d的疼痛不适感,1wk后角膜缺损修复度,以及1mo后自觉视觉质量受影响的相关因素。结果:三组患者术后疼痛感比较,术后1、3、5d戴镜组疼痛感均明显低于rb-bFGF组和空白组;术后3、5d时rb-bFGF组的疼痛感低于空白组。术后1wk,戴镜组和rb-bFGF组角膜修复度均较空白组高,但戴镜组和rb-bFGF组间角膜修复度无差异(P>0.05)。术后1mo,视觉质量是否受影响与异物位置相关,越靠近瞳孔区,影响越大(rs=0.635,P<0.001)。结论:SCL可在早期有效缓解角膜深层异物剔除术后疼痛感,rb-bFGF滴眼液和SCL均可加速角膜的修复生长,而视觉质量是否受影响与角膜深层异物位置有关。·AIM:To investigate the repairment of wound by using soft contact lenses and rb-bFGF eye drops after deep foreign body removal.·METHODS:Patients with deep corneal foreign body(72 cases,72 eyes) were randomly separated into three groups and received surgery to remove the foreign bodys.Patients in group C only accepted levofloxacin eye drops and ofloxacin eye ointment while patients in group A wore soft contact lenses and group B received rb-bFGF eye drops as an extra after operation.The corneal irritation and pain(1,3,5 d),wound healing(1 wk) and relevant factors in visual acuity impairment(1 mo) were observed after deep foreign body removal.·RESULTS:Corneal irritation and pain scores in group A were significantly lower than that in the other two groups at 1,3 and 5 d after operation.Patients felt less painful in group B than group C at 3 and 5 d.Corneal wound healing in groups A and B was significantly higher than group C at 1 wk after surgery(P> 0.05).The closer corneal foreign body was to the pupil area,the more vision was affected after 1 mo operation(rs=0.635,P<0.05).·CONCLUSION:Soft contact lenses can effectively alleviate eye irritation after deep corneal foreign body removal in early time.Both SCL and rb-bFGF eye drops can accelerate the recovery of corneal wounds.Visual acuity impairment was closely related to the location of foreign body in deep corneal.

关 键 词：角膜深层异物 软性接触镜 rb-bFGF滴眼液 缺损修复 术后 

分 类 号：R779.6[医药卫生—眼科]