康柏西普联合激光治疗缺血型视网膜静脉阻塞继发黄斑水肿  

Efficacy of intravitreal Conbercept combined with laser photocoagulation for macular edema secondary to ischemic retinal vein occlusion

作　　者：吴素兰 毛剑波 沈丽君 林丽 陈亦棋 张赟 陶继伟 张彩云 邵伊润 Su-Lan Wu;Jian-Bo Mao;Li-Jun Shen;Li Lin;Yi-Qi Chen;Yun Zhang;Ji-Wei Tao;Cai-Yun Zhang;Yi-Run Shao(Eye Fundus Center,the Affiliated Eye Hospital of Wenzhou Medical University,Hangzhou 310000,Zhejiang Province,China)

机构地区：[1]温州医科大学附属眼视光医院杭州院区眼底病中心

出　　处：《国际眼科杂志》2020年第2期350-353,共4页International Eye Science

基　　金：温州市科技计划项目(No.Y20190649)~~

摘　　要：目的:观察玻璃体腔注射康柏西普联合周边视网膜激光治疗缺血型视网膜静脉阻塞继发黄斑水肿(RVO-ME)的疗效。方法:回顾性病例研究。收集2014-10/2018-11在温州医科大学附属眼视光医院诊断为缺血型RVO-ME的患者39例39眼,其中CRVO患者14例14眼,BRVO患者25例25眼。所有患者均予玻璃体腔注射康柏西普联合周边视网膜激光光凝治疗。分别于治疗前后检测最佳矫正视力(BCVA)和黄斑中心凹厚度(CMT)。结果:治疗后1、2、3、6mo,本组患者BCVA(0.67±0.49、0.56±0.41、0.62±0.52、0.47±0.40)均较治疗前(0.99±0.57)显著改善(P <0.05),CMT (299.5±188.1、254.8±127.6、294.1±174.9、228.8±64.45μm)均较治疗前(608.4±214.7μm)显著下降(P<0.05)。治疗后6mo BCVA与治疗前基线BCVA呈正相关(r=0.78,P<0.05),而与治疗前CMT无明显相关性(r=0.25,P=0.13)。结论:玻璃体腔注射康柏西普联合周边视网膜激光光凝治疗缺血型RVO-ME疗效确切,可有效改善视力,降低CMT。·AIM:To investigate the effects of intravitreal conbercept combined with peripheral laser photocoagulation for ischemic RVO-ME.·METHODS:A retrospective clinical study.Totally 39 patients(39 eyes) were included in this study since 2014-10 to 2018-11,who were diagnosed ischemic RVO-ME in Eye Hospital of Wenzhou Medical University.There were14 CRVO and 25 BRVO.All patients were given intravitreal conbercept combined with peripheral laser photocoagulation.BCVA,OCT were examined before and after treatment.·RESULTS:BCVA of 1,2,3,6 mo(0.67±0.49,0.56±0.41,0.62±0.52,0.47±0.40) after treatment was significantly improved compared to base line(0.99±0.57)(P<0.05).CMT of 1,2,3,6 mo(299.5±188.1,254.8±127.6,294.1±174.9,228.8±64.45μm) after treatment was significantly decreased compared to base line(608.4±214.7μm)(P<0.05).BCVA of 6 mo was positively correlated with base line BCVA(r=0.78,P <0.05),while there was no correlation with base line CMT(r=0.25,P=0.13).·CONCLUSION:Intravitreal conbercept combined with peripheral laser photocoagulation is a effective approach for ischemic RVO-ME,which can significantly improve BCVA and decrease CMT.

关 键 词：视网膜静脉阻塞 黄斑水肿 康柏西普 周边视网膜激光 最佳矫正视力 

分 类 号：R774[医药卫生—眼科]