外周血淋巴细胞和单核细胞比值对预测弥漫大B细胞淋巴瘤复发的研究  

Peripheral blood lymphocyte and monocyte ratio predicts relapse in patients with diffuse large B cell lymphoma

作　　者：杨婷婷[1] 王艳艳 王宝宏[2] Yang Tingting;Wang Yanyan;Wang Baohong(Department of Internal Medicine,Weifang Medical College,Weifang 261053,China;Department of Hematology,Weifang People's Hospital,Weifang 261000,China)

机构地区：[1]潍坊医学院内科学教研室,山东潍坊261053 [2]潍坊市人民医院血液内科,山东潍坊261000

出　　处：《临床荟萃》2019年第12期1089-1093,共5页Clinical Focus

摘　　要：目的研究外周血中淋巴细胞和单核细胞比值(LMR)与弥漫性大B细胞淋巴瘤(DLBCL)患者临床特征的关系,判断预后及预测复发情况。方法回顾性收集初治126例DLBCL患者的临床资料,应用统计学方法分析其与临床特征、预后、复发的相关关系,探讨其预测复发的价值。结果低LMR(<2.25)组患者常伴随B症状、国际预后指数(IPI)评分增高、临床分期较晚、β2-微球蛋白水平升高(P<0.05)。126例患者有43例(37.7%)复发,中位复发时间12(2~70)个月。多因素分析(OR=2.586,P=0.028)提示随访时低LMR与复发显著相关,低LMR比高LMR复发风险高,并且低LMR与较短总生存时间(OS)及无病生存时间(PFS)有关(OS:P=0.015;PFS:P=0.006)。结论这项研究表明,LMR<2.25提示不良的预后,随诊时较低的LMR可以用作预测DLBCL患者复发的指标。Objective To investigate the relationship between peripheral blood lymphocyte and monocyte ratio(LMR)and clinical features of patients with diffuse large B-cell lymphoma(DLBCL),and to judge the prognosis and predict the relapse.Methods The clinical data of 126 DLBCL patients was retrospectively analyzed.Statistical methods were used to analyze the relationship between clinical features,prognosis and relapse,and to explore the value of predicting relapse.Results Patients in the low LMR(<2.25)group were often accompanied by B symptoms,high IPI score,late clinical stage,and elevatedβ2-microglobulin levels(P<0.05).Totally 43 cases of 126 patients(37.7%)suffered relapse,with a median relapse time of 12(2-70)months.Multivariate analysis(OR=2.586,P=0.028)showed that low LMR was significantly associated with relapse at follow-up,low LMR was more risky than high LMR,and low LMR was related to shorter overall survival(OS)and disease-free survival(DFS)(OS:P=0.015;PFS:P=0.006).Conclusion This study suggests that when LMR is less than 2.25,it indicates poor prognosis.And during the follow-up,a lower LMR can be used as a marker to predict relapse in patients with DLBCL.

关 键 词：淋巴瘤 B细胞 淋巴细胞 单核细胞 复发 预后 

分 类 号：R773[医药卫生—眼科]