胃癌组织中B7-H4的表达及其与临床病理特征的相关性分析  

Expression of B7-H4 in gastric carcinoma tissue and its correlations with clinicopathological features

作　　者：董华承[1] 吴爽[1] 周易[1] 范丽昕[1] 付静[1] DONG Huacheng;WU Shuang;ZHOU Yi;FAN Lixin;FU Jing(Department of Oncology of the Third People’s Hospital of Dalian,Dalian 116033 Liaoning,China)

机构地区：[1]大连市第三人民医院肿瘤科

出　　处：《中国民康医学》2019年第22期1-3,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨胃癌组织中B7-H4的表达及其与临床病理特征的相关性。方法:选取80例临床病理确诊的胃癌患者为研究对象,收集患者胃癌组织及癌旁正常组织,应用免疫组织化学染色法检测样本组织中B7-H4的表达,分析其与临床病理特征的关系。结果:B7-H4在胃癌组织中呈弥漫性分布,主要表达于肿瘤细胞的胞浆和(或)胞膜中,而B7-H4在癌旁正常组织中不表达或呈弱阳性表达;B7-H4在胃癌组织中的阳性表达率为81.25%,明显高于癌旁正常组织的28.75%,差异有统计学意义(P<0.05);B7-H4的阳性表达与肿瘤分化程度、临床分期、浸润程度及淋巴结转移密切相关,肿瘤分化程度越低,临床分期越高,有深层浸润和淋巴结转移的胃癌组织中B7-H4的阳性表达率越高。结论:B7-H4在胃癌组织中呈高表达,其与胃癌的临床病理特征存在相关性,探究B7-H4在胃癌肿瘤微环境中的阳性表达,对预测胃癌的发生、发展及免疫治疗具有重要意义。Objective: To investigate expression of B7-H4 in gastric carcinoma tissue and its correlations with clinicopathological features. Methods: 80 patients with gastric carcinoma diagnosed by clinical pathology were selected as the subjects. The gastric carcinoma tissue and normal adjacent tissues were collected. The expression of B7-H4 was detected by immunohistochemical staining, and its correlations with clinicopathological features were analyzed. Results: B7-H4 was diffusely distributed in the gastric carcinoma tissue and was mainly expressed in the cytoplasm and/or membrane of tumor cells, while B7-H4 was not expressed or weakly positively expressed in the normal adjacent tissues. The positive expression rate of B7-H4 in the gastric carcinoma tissue was 81.25%, which was significantly higher than 28.75% of the normal adjacent tissues, and the difference was statistically significant(P<0.05). The positive expression of B7-H4 was closely related to the degree of tumor differentiation, clinical stage, degree of invasion and lymph node metastasis. The expression of B7-H4 was the highest in the gastric carcinoma tissues with lower tumor differentiation, higher clinical stage, deep infiltration and lymph node metastasis. Conclusions: B7-H4 is highly expressed in the gastric carcinoma tissue, and its expression is related to the clinicopathological features of gastric cancer. Therefore, it is important to explore the positive expression of B7-H4 in gastric microenvironment in order to predict the occurrence, development and immunotherapy of gastric cancer.

关 键 词：胃癌组织 B7-H4 临床病理特征 相关性 

分 类 号：R735.2[医药卫生—肿瘤]