乳腺浸润性导管癌超声特征与ER、PR、CerB-2、Ki-67表达的相关性  

Correlation between ultrasonographic features and expression of ER, PR,CerB-2, and Ki-67 in breast invasive ductal carcinoma

作　　者：杨艳 张文[1] 金晶 封淏 孙红光[1] 丁永玲[2] 诸林海[3] Yang Yan;Zhang Wen;Jin Jing;Feng Hao;Sun Hongguang;Ding Yongling;Zhu Linhai(Department of Ultrasound,Affiliated Hospital of Yangzhou University,Yangzhou 225100,China;Department of Pathology,Affiliated Hospital of Yangzhou University,Yangzhou 225100,China;Department of Nail and Breast Surgery,Affiliated Hospital of Yangzhou University,Yangzhou 225100,China)

机构地区：[1]扬州大学附属医院超声科,225100 [2]扬州大学附属医院病理科,225100 [3]扬州大学附属医院甲乳外科,225100

出　　处：《中华临床医师杂志（电子版）》2019年第5期333-338,共6页Chinese Journal of Clinicians(Electronic Edition)

基　　金：江苏省扬州市科技计划项目(YZ2018078);江苏省扬州市“十三五”科教强卫工程项目(LJRC201819)

摘　　要：目的探讨乳腺浸润性导管癌(IDC)超声特征与雌激素受体(ER)、孕激素受体(PR)、人类上皮生长因子受体2(CerB-2)、增殖细胞核抗原(Ki-67)表达的相关性。方法收集2015年6月至2019年2月我院收治的189例IDC患者的临床资料,对超声资料及分子病理学指标进行分析。结果 ER、PR、CerB-2、Ki-67蛋白在IDC中的阳性表达率分别为63.4%(120/189)、52.9%(100/189)、45.5%(86/189)、65.6%(124/189)。IDC超声表现为肿块边缘有毛刺征患者的ER、PR阳性率高于无毛刺征患者,差异有统计学意义(70.0%vs. 56.2%,60.0%vs. 44.9%,P <0.05),有微钙化患者的CerB-2、Ki-67阳性率高于无钙化患者,差异有统计学意义(53.4%vs. 38.8%,73.2%vs. 59.2%,P <0.05),血流信号丰富患者的CerB-2、Ki-67阳性率高于乏血供患者,差异有统计学意义(52.2%vs. 35.8%,72.1%vs. 56.4%,P <0.05),有腋窝可疑淋巴结患者的CerB-2阳性率高于无可疑淋巴结患者,差异有统计学意义(54.3%vs. 34.8%,P <0.05)。结论 IDC的超声特征与ER、PR、CerB-2、Ki-67的表达有相关性,超声检查可为乳腺癌的术前诊断、治疗及评估预后提供重要依据。Objective To explore the correlation between ultrasonographic features and the expression of estrogen receptor(ER), progesterone receptor(PR), human epidermal growth factor receptor 2(CerB-2), and Ki-67 in breast invasive ductal carcinoma(IDC). Methods The data of 189 IDC patients who were treated at our hospital from June 2015 to February 2019 were collected. Their ultrasonographic data and immunohistochemical pathologic results were analyzed. Results The positive rates of ER, PR, CerB-2, and Ki-67 in IDC were 63.4%(120/189), 52.9%(100/189), 45.5%(86/189), and 65.6%(124/189), respectively. The positive expression rates of ER and PR in patients with spiculation were significantly higher than those in patients without(70.0% vs. 56.2%, 60.0% vs. 44.9%, P < 0.05). The positive expression rates of CerB-2 and Ki-67 in patients with microcalcification were significantly higher than those in patients without(53.4% vs. 38.8%, 73.2% vs. 59.2%, P < 0.05). The positive expression rates of CerB-2 and Ki-67 in patients with rich blood flow signals were significantly higher than those in patients with poor blood flow signals(52.2% vs. 35.8%, 72.1% vs. 56.4%, P < 0.05). The positive expression rate of CerB-2 in patients with suspicious positive lymph nodes was higher than that in patients without(54.3% vs. 34.8%, P < 0.05). Conclusion There is a correlation between ultrasonographic features and the expression of ER, PR, CerB-2, and Ki-67 in IDC of the breast. The ultrasonographic features may provide more evidence for the diagnosis, clinical treatment, and prognosis of IDC of the breast.

关 键 词：乳腺浸润性导管癌 超声 雌激素受体 孕激素受体 人类上皮生长因子受体2 增殖细胞核抗原 

分 类 号：R737.9[医药卫生—肿瘤] R445.1[医药卫生—临床医学]