胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ及PGR检验对慢性胃病变的临床诊断价值  

Clinical diagnostic value of pepsinogen Ⅰ, pepsinogen Ⅱ and PGR test for chronic gastric lesions

作　　者：杨敏[1] YANG Min(the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710089,China)

机构地区：[1]西安交通大学第一附属医院

出　　处：《临床医学研究与实践》2020年第2期133-135,共3页Clinical Research and Practice

摘　　要：目的探讨胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)及PGR检验对慢性胃病变的临床诊断价值。方法选取我院收治的慢性胃病变患者253例,根据疾病类型分为慢性萎缩性胃炎组(n=87)、胃十二指肠溃疡组(n=71)、高级别上皮内瘤变组(n=19)、低级别上皮内瘤变组(n=46)和胃癌组(n=30),再选取同期于我院行健康体检者83例为对照组。比较六组的PGⅠ、PGⅡ水平、PGR及PGⅠ、PGⅡ和PGR对慢性胃病变的诊断效能。结果胃十二指肠溃疡组的PGⅠ水平最高,其次为对照组,胃癌组最低(P<0.05)。对照组的PGⅡ水平最低,胃癌组最高(P<0.05)。胃十二指肠溃疡组的PGR最高,其次为对照组,胃癌组最低(P<0.05)。PGR检出胃病变的准确度、特异度、阳性预测值和阴性预测值最高,PGⅡ最低,三种检测方法的上述指标比较,差异显著(P<0.05),但三种检测方法的灵敏度无显著差异(P>0.05)。结论 PGⅠ、PGⅡ和PGR用于慢性胃病变诊断中的价值较高。Objective To investigate the clinical diagnostic value of pepsinogenⅠ(PGⅠ), pepsinogenⅡ(PGⅡ) and PGR test for chronic gastric lesions. Methods A total of 253 patients with chronic gastric lesions admitted in our hospital were selected and divided into chronic atrophic gastritis group(n=87), gastroduodenal ulcer group(n=71), high-grade intraepithelial neoplasia group(n=19), low-grade intraepithelial neoplasia group(n=46) and gastric cancer group(n=30)according to the types of disease, 83 people who underwent physical examination in our hospital at the same time were selected as control group. The levels of PGⅠ, PGⅡ, PGR in the six groups and the diagnostic efficiency of PGⅠ, PGⅡand PGR for chronic gastric lesions were compared. Results The level of PGⅠ in the gastroduodenal ulcer group was the highest, followed by the control group, that in the gastric cancer group was the lowest( P <0.05). The PG Ⅱ in the control group was the lowest, that in the gastric cancer group was the highest(P <0.05). The PGR was highest in the gastroduodenal ulcer group, followed by the control group, that in the gastric cancer group was lowest( P <0.05).Accuracy, specificity, positive predictive value and negative predictive value of gastric lesions detected by PGR were the highest, which of PG Ⅱ were the lowest, there were statistically significant differences in the above indexes of the three detection methods(P <0.05), but there was no statistically significant difference in the sensitivity of the three detection methods(P>0.05). Conclusion PGⅠ, PGⅡ and PGR have higher value in the diagnosis of chronic gastric lesions.

关 键 词：慢性胃病变 胃蛋白酶原Ⅰ 胃蛋白酶原Ⅱ PGR 

分 类 号：R573[医药卫生—消化系统]