系统免疫-炎症指数与晚期非小细胞肺癌预后的关系  

Relationship between system immune-inflammation index and prognosis of advanced non-small cell lung cancer

作　　者：郭静 王又君 褚会松 曲杰[2] 赵如涵[1] 周鑫 吕喜英[2] GUO Jing;WANG Youjun;CHU Huisong;QU Jie;ZHAO Ruhan;ZHOU Xin;LYU Xiying(Chengde Medical College,Chengde Medical College Affiliated Hospital,Chengde 067000,China;Department of Oncology,Chengde Medical College Affiliated Hospital,Chengde 067000,China)

机构地区：[1]承德医学院,承德067000 [2]承德医学院附属医院肿瘤科,承德067000

出　　处：《中国癌症防治杂志》2019年第6期508-512,共5页CHINESE JOURNAL OF ONCOLOGY PREVENTION AND TREATMENT

摘　　要：目的探讨系统免疫-炎症指数(system immune-inflammation index,SII)对晚期非小细胞肺癌患者预后的评估价值。方法收集2013年10月至2018年12月于承德医学院附属医院就诊的300例晚期非小细胞肺癌患者的临床资料。通过ROC曲线计算SII最佳截点值,并根据最佳截点值分为高SII组(SII≥767.24×10~9,n=168)和低SII组(SII<767.24×10~9,n=132),比较两组患者的临床病理特征及总生存期,并采用Cox回归分析SII与患者预后的关系。结果 SII与晚期非小细胞肺癌患者临床分期、KPS评分有关(P<0.05)。低SII组中位生存期高于高SII组(21个月vs 13个月,χ~2=16.824,P<0.001)。单因素Cox回归结果显示,病理类型、临床分期、吸烟情况、KPS评分、SII、血红蛋白水平和治疗方案均与晚期非小细胞肺癌患者预后有关(P<0.05);多因素Cox回归显示,SII≥767.24×10~9是晚期非小细胞肺癌患者总生存期的独立危险因素(HR=1.416,95%CI:1.039~1.930,P=0.028)。结论高SII是晚期非小细胞肺癌患者总生存期的独立危险因素,SII可作为预后评估指标。Objective To investigate the value of system immune-inflammation index(SII)in the prognosis of patients with advanced non-small cell lung cancer(NSCLC). Methods Clinical data of 300 patients with advanced NSCLC who were admitted to the Chengde Medical College Affiliated Hospital from October 2013 to December 2018 were collected. ROC curve was used to calculate the best SII cutoff value,and patients were divided into high SII group(SII≥767.24×10~9,n=168)and low SII group(SII<767.24×10~9,n=168)according to the best cutoff value. The clinicopathological characteristics and overall survival of the two groups of patients were compared,and the relationship between SII and prognosis was analyzed by Cox regression. Results SII was associated with clinical staging and KPS score(P<0.05). The median survival in the low SII group was higher than that in the high SII group(21 months vs 13 months,χ~2=16.824,P <0.001).Univariate Cox regression showed that pathological type,clinical stage,smoking,KPS score,SII,Hb level and treatment regimen were all associated with the prognosis of advanced NSCLC patients(P <0.05).Multivariate Cox regression showed that SII ≥767.24 ×10~9 was an independent risk factor for the overall survival of advanced NSCLC patients(HR=1.416,95%CI:1.039-1.930,P=0.028). Conclusion High SII is an independent risk factor for the overall survival of patients with advanced NSCLC,which can be used as a prognostic indicator.

关 键 词：非小细胞肺癌 系统免疫-炎症指数 预后 

分 类 号：R734.2[医药卫生—肿瘤]