癌症病人阿片类药物相关性便秘最佳循证实践方案的制订和应用  

Development and application of the best evidence-based protocol for opioid-induced constipation in cancer patients

作　　者：王丽[1] 陈佩娟[1] 杜真真[1] 陈春雨[1] 张露[1] 张兰芳[1] WANG Li;CHEN Peijuan;DU Zhenzhen;CHEN Chunyu;ZHANG Lu;ZHANG Lanfang(Nanfang Hospital,Southern Medical University,Guangdong 510515 China)

机构地区：[1]南方医科大学南方医院

出　　处：《护理研究》2020年第1期18-23,共6页Chinese Nursing Research

基　　金：2017年度南方医院护理创优-循证实践专项立项资助项目，编号：2017EBNb003

摘　　要：[目的]制定癌症病人阿片类药物相关性便秘管理的最佳循证实践方案,并应用于临床。[方法]检索相关领域的临床实践指南、系统评价等循证资源,获取最佳证据并进行分析,形成“癌症病人阿片类药物相关性便秘管理的最佳实践方案”,将该方案应用于入住放疗科的癌症病人中检验其效果。[结果]跟踪随访8周后,观察组便秘发生率为26.53%,显著高于对照组(54.90%),观察组肠功能指数评分显著低于对照组,生活质量评分[(77.77±11.13)分]显著高于对照组[(62.07±10.52)分],差异均有统计学意义(P<0.05)。[结论]基于循证的最佳实践方案可改善癌症病人阿片类药物相关性便秘的症状,提升病人的生活质量,为此类病人的临床管理提供依据及参考。Objective:To develop and apply an evidence-based protocol for opioid-induced constipation(OIC)in cancer patients.Methods:The evidence-based resources,such as clinical practice guidelines and systematic evaluation,was retrieved in related fields,and analyzed to form the best evidence-based protocol for opioid-induced constipation in cancer patients.And the protocol was applied to cancer patients admitted to radiotherapy department to test its clinical effect.Results:After eight weeks of follow-up,the incidence of constipation in the observation group was 26.53%,which was significantly higher than that in the control group(54.90%).The Bowel Function Index of the observation group was significantly lower than that in the control group.And the quality of life score of observation group(77.77±11.13)was significantly higher than that in the control group(62.07±10.52).The differences were all statistically significant(P<0.05).Conclusion:Evidence-based practices could improve OIC symptoms and quality of life in cancer patients,and provide evidence and reference for clinical management of cancer patients.

关 键 词：癌症 阿片类药物相关性便秘 循证实践 生活质量 肠功能指数 循证护理 

分 类 号：R47[医药卫生—护理学]