血清CEA、CA19-9、CA50联合检测对胰腺癌手术可切除性的预测价值研究  

Prediction of Combination Detection of Serum CEA, CA19-9 and CA50 Levels for Surgical Resectability of Pancreatic Cancer

作　　者：程勇[1] 李领侠[2] 曾文斌 CHENG Yong;LI Ling-xia;ZENG Wen-bin(Shaanxi Energy Institute,Xi'an 710613,China;Department of Retired Veteran Cadres,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China;Department of Anesthesiology,the Cancer Hospital of Shaanxi,Xi'an 710061,China)

机构地区：[1]陕西能源职业技术学院实践教学管理处,西安710613 [2]西安交通大学第二附属医院老年干部科,西安710004 [3]陕西省肿瘤医院麻醉科,西安710061

出　　处：《临床误诊误治》2020年第1期84-87,共4页Clinical Misdiagnosis & Mistherapy

基　　金：陕西省科技攻关项目(2014K11-02-01-04)

摘　　要：目的探讨血清癌胚抗原(CEA)、癌抗原19-9(CA19-9)和癌抗原50(CA50)水平对胰腺癌手术可切除性的预测价值。方法选取2015年1月—2017年5月我院收治的86例胰腺癌作为研究对象,根据手术方式的不同分为手术可切除组(根治术治疗)和手术不可切除组(姑息性治疗),回顾性分析两组临床及随访资料,分析胰腺癌患者不可手术切除的影响因素及CEA、CA19-9、CA50联合检测对胰腺癌手术可切除性的预测价值。结果86例胰腺癌可切除34例,可切除率为39.53%。非条件多因素logistic回归分析显示,CA19-9、CEA、CA50升高及TNM分期Ⅲ~Ⅳ期为胰腺癌不可手术切除的影响因素;CEA、CA19-9、CA50联合检测预测胰腺癌手术可切除性的灵敏度和特异度均高于各指标单独检测(P<0.05)。结论CA19-9、CEA、CA50升高及TNM分期Ⅲ~Ⅳ期为胰腺癌不可手术切除的影响因素,可将CEA、CA19-9、CA50联合检测作为预测胰腺癌手术可切除性的有效方法。Objective To investigate the predictive value of serum carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9)and carbohydrate antigen 50(CA50)levels for surgical resectability of pancreatic cancer.Methods A total of 86 cases with pancreatic cancer admitted to the Second Affiliated Hospital of Xi'an Jiaotong University from January 2015 to May 2017 were enrolled.According to the different surgical methods,they were divided into resectable group(radical surgery)and unresectable group(palliative treatment).The clinical and follow-up data of all patients were retrospectively analyzed.The relevant influencing factors of non-surgical resection of patients with pancreatic cancer and the predictive value of combination detection of CEA,CA19-9 and CA50 in resectability were analyzed.Results Of 86 cases with pancreatic cancer,34 cases were surgically resectable and the resectability rate was 39.23%.Non-conditional multivariate logistic regression analysis showed that higher CA19-9,CEA and CA50 levels and stageⅢ-Ⅳof TNM staging were influencing factors of unresectable surgery in patients with pancreatic cancer.The sensitivity and specificity of combined detection of CA19-9,CEA,and CA50 in predicting surgical resection of pancreatic cancer were higher than those of indicators alone(P<0.05).Conclusion Increased CA19-9,CEA,CA50 and stageⅢ-Ⅳof TNM staging are influencing factors of unresectable surgery in patients with pancreatic cancer.Therefore,combination detection of CA19-9,CEA and CA50 can be used as an effective method for predicting surgical resectability in patients with pancreatic cancer.

关 键 词：胰腺肿瘤 癌胚抗原 抗原 肿瘤相关 碳水化合物 抗原 肿瘤 预测 

分 类 号：R735.9[医药卫生—肿瘤]