AML合并自发性肿瘤溶解综合征及骨髓坏死一例  

Acute myeloid leukemia complicated with spontaneous tumor lysis syndrome and bone marrow necrosis: one case report

作　　者：孟杰 齐林 成志勇[3] 付建珠 柳倩[3] 王素云 Meng Jie;Qi Lin;Cheng Zhiyong;Fu Jianzhu;Liu Qian;Wang Suyun(Department of Oncology and Hematology,Second Affiliated Hospital of Hainan Medical College,Haikou 570000,China)

机构地区：[1]海南医学院第二附属医院肿瘤内血液科,海口570000 [2]承德医学院研究生院,承德067000 [3]保定市第一医院血液内科,保定071000 [4]深圳市龙华区中心医院血液内科,深圳518000

出　　处：《新医学》2020年第1期67-70,共4页Journal of New Medicine

摘　　要：肿瘤溶解综合征(TLS)是因大量肿瘤细胞溶解、破坏导致细胞内的核酸、磷、钾等成分释放入血液循环,引发相关代谢紊乱的症候群,死亡风险极高。该文报告1例发生自发性TLS及骨髓坏死的急性髓系白血病(AML)患者,其为63岁女性,于化学治疗前即出现自发性TLS、急性肾功能衰竭及DIC,在治疗过程中出现骨髓坏死。患者接受小剂量化学治疗及连续性床旁血液滤过治疗,以及水化治疗、碱化尿液、补钙、输注红细胞及血小板等对症治疗后,最终成功被救治。Tumor lysis syndrome(TLS) is caused by the release of nucleic acid, phosphorus, potassium and other substances from cells into the blood circulation due to the lysis and destruction of a large quantity of tumor cells, leading to the metabolism-related disorder syndrome and high risk of death. In this article, one case of AML complicated with spontaneous TLS and bone marrow necrosis was reported. The 63-year-old female patient presented with spontaneous TLS, acute renal failure and disseminated intravascular coagulation prior to chemotherapy. She was successfully healed after low-dose chemotherapy, continuous bedside hemofiltration, hydration therapy, alkalized urine, calcium supplement and infusion of red blood cells and platelets.

关 键 词：急性髓系白血病 肿瘤溶解综合征 骨髓坏死 

分 类 号：R733.71[医药卫生—肿瘤]