重复经颅磁刺激治疗偏头痛患者的临床研究  

Clinical study of repetitive transcranial magnetic stimulation in migraine

作　　者：张晓玲[1] 何伟亮[1] 孙海青 赵雪平[1] 武晓园 王贺波[1] Zhang Xiaoling;He Weiliang;Sun Haiqing;Zhao Xueping;Wu Xiaoyuan;Wang Hebo(Department of Neurology,the Hebei General Hospital,Shijiazhuang 050000,China)

机构地区：[1]河北省人民医院神经内科

出　　处：《脑与神经疾病杂志》2020年第1期11-13,共3页Journal of Brain and Nervous Diseases

基　　金：国家自然科学青年科学基金项目(81801312);2019度河北省医学科学研究课题计划(20190257)

摘　　要：目的观察重复经颅磁刺激(rTMS)治疗偏头痛的疗效和安全性。方法入选的96例偏头痛患者分为rTMS组和假刺激组,每组48例,并记录患者一般资料。rTMS组患者接受经颅磁刺激治疗,隔日1次,15次为一疗程,并进行随访。假刺激组使用伪线圈,不产生治疗效应。记录头痛频率改善、视觉模拟评分量表(VAS)评分改善情况、临床疗效和不良反应等。结果与假刺激组相比,rTMS组患者在头痛发作频率和VAS改善以及临床疗效上均有所好转,差异有统计学意义(P<0.05)。随访过程中rTMS组3例患者出现头晕乏力,但均未发生严重不良反应。结论 tTMS治疗偏头痛是有效且相对安全的方法。Objective To observe the efficacy and safety of repetitive transcranial magnetic stimulation(rTMS) in migraine. Methods 96 migraine patients were divided into rTMS group and sham stimulation group. Each group includes 48 patients. Their general data were recorded. Patients in the rTMS group were treated with rTMS, once every other day, 15 times as a course, and followed up. No therapeutic effect was generated in the sham stimulation group using dummy coils. The improvement of headache frequency, visual analogue scale(VAS) score, clinical efficacy and adverse reactions were recorded. Results Compared with the sham stimulation group, the rTMS group showed significant improvement in headache attack frequency, VAS and clinical efficacy(P<0.05). During the follow-up, 3 patients in rTMS group showed dizziness and fatigue, but no serious adverse reactions occurred. Conclusion rTMS is a relatively effective and safe treatment for migraine.

关 键 词：偏头痛 重复经颅磁刺激 临床疗效 安全性 

分 类 号：R747.2[医药卫生—神经病学与精神病学]