肿瘤间质比在乳腺癌预后评估中的价值研究  

Value of tumor-stroma ratio in the prediction of the prognosis of breast cancer

作　　者：单宏杰[1] 肖迎利 马骖[1] 谢长华 封杨 夏艳 SHAN Hong-jie;XIAO Ying-li;MA Can;XIE Chang-hua;FENG Yang;XIA Yan(Department of Oncology Surgery,Suzhou Hospital Affiliated to Anhui Medical University,Suzhou Anhui 234000,China;Department of Pathology,Suzhou Hospital Affiliated to Anhui Medical University,Suzhou Anhui 234000,China)

机构地区：[1]安徽医科大学附属宿州临床学院肿瘤外科,安徽宿州234000 [2]安徽医科大学附属宿州临床学院病理科,安徽宿州234000

出　　处：《蚌埠医学院学报》2019年第12期1631-1633,共3页Journal of Bengbu Medical College

摘　　要：目的:了解肿瘤间质比(TSR)在乳腺癌预后的评估作用及其与临床病理关系。方法:收集120例乳腺癌病人肿瘤组织标本经HE染色后在显微镜下寻找肿瘤浸润明显区域3个视野寻找肿瘤细胞,取最高值。并随访病人的预后情况,分析TSR与乳腺癌临床病理关系及预后的关系。结果:TSR与乳腺癌的淋巴结转移(r=0.302)、组织学分级(r=0.295)具有相关性(P<0.01)。预后的单因素和多因素分析均显示TSR是乳腺癌的独立预后因素(P<0.01)。结论:TSR是乳腺癌的独立预后因素,且其检测具有重复性高、操作简单等优势,值得临床推广。Objective:To explore the value of tumor-stroma ratio(TSR)in the assessment of the prognosis of breast cancer,and its correlation with clinicopathology.Methods:One hundred and twenty tumor tissue samples of breast cancer patients were stained using HE,the tumor cells in three visual fields with obvious tumor infiltration were calculated to obtain the highest value under the microscope.All cases were followed up,and the relationship between TSR,and clinicopathology and prognosis of breast cancer were analyzed.Results:The TSR was correlated with the lymph node metastasis and histological grade(P<0.01).The single and multivariate analysis of prognosis showed that the TSR was an independent prognostic factor of breast cancer(P<0.01).Conclusions:The TSR is an independent prognostic factor of breast cancer,which has high repeatability and simple operation,and is worthy of clinical promotion.

关 键 词：乳腺肿瘤 肿瘤间质比 预后 

分 类 号：R737.9[医药卫生—肿瘤]