阴道残端三维适形近距离补量放疗中膀胱容量的变化对正常器官受量的影响  

Effect of changes of bladder volume on biological dosage capacity of the normal organs in three dimensional conformal brachytherapy for vaginal stump

作　　者：陈杰[1] 李成[1] 管建 施润君 周俊东[1] 杨益琴 胡群超[1] CHEN Jie;LI Cheng;GAUN Jian;SHI Runjun;ZHOU Jundong;YANG Yiqin;HU Qunchao(Department of Tumor Radiotherapy,Suzhou Hospital Affiliated to Nanjing Medical University,Suzhou,Jiangsu,215000)

机构地区：[1]南京医科大学附属苏州医院肿瘤放疗科

出　　处：《实用临床医药杂志》2020年第2期6-8,共3页Journal of Clinical Medicine in Practice

基　　金：国家重点研发计划项目(2018YFA028800)

摘　　要：目的比较宫颈癌患者术后阴道残端三维适形近距离补量放疗中膀胱容量的变化对于阴道残端周围正常器官受量的影响。方法选取本科室就诊的妇科肿瘤患者15例,对阴道残端行近距离放疗。实施三维适形近距离放疗时将膀胱排空,之后分别注入生理盐水50、100、150 mL,比较不同膀胱容量下小肠、直肠、膀胱及乙状结肠的正常器官距放射源最近的2cm^3体积的剂量(D2cm^3)。结果小肠D2cm^3在膀胱排空时较膀胱50、100、150 mL充盈状态时都高(P<0.01),膀胱容量的变化对直肠、膀胱、乙状结肠的D2cm^3无显著影响(P>0.05)。结论膀胱容量的变化改变了小肠的D2cm^3,但并不改变直肠、乙状结肠、膀胱的D2cm^3。阴道残端补量治疗时,膀胱充盈度为50mL最为合适,可以降低小肠的受量。Objective To compare the influence of changes of bladder volume on biological dosage capacity of the normal organs in three dimensional conformal brachytherapy for vaginal stump.Methods A total of 15 gynecological tumors patients were included in this study,and were given three dimensional conformal brachytherapy in vaginal stump.During three-dimensional conformal brachytherapy,the bladder was emptied and infused by saline at a dosage of 50,100 and 150 mL,respectively.The values of the dose of 2cm^3 of normal organ closest to the radiation source(D2cm^3)of small intestine,rectum,bladder and sigmoid colon were compared at different bladder volumes.Results The D2cm 3 of small intestine in emptying was higher than 50,100 and 150 mL saline(P<0.01).The change of bladder volume had no significant effect on values of D 2 cm^3 of rectum,bladder,and sigmoid colon.Conclusion The changes of bladder volume have an impact on D2cm^3 of the small intestine,but no influence on the D2cm^3 of rectum,sigmoid and bladder.For retrofitting of the vaginal stump,bladder filling of 50 mL is appropriate,which can reduce the dosage of small intestine.

关 键 词：宫颈癌手术 子宫内膜癌 剂量 膀胱容量 三维适形近距离治疗 

分 类 号：R737.33[医药卫生—肿瘤]