Hippo信号通路在宫腔粘连纤维化中的研究进展  

Research progress of Hippo signaling pathway in intrauterine adhesion fibrosis

作　　者：丁媛 刘莹[1] 武露明 张学红[1] 王一青[1] Ding Yuan;Liu Ying;Wu Luming;Zhang Xuehong;Wang Yiqing(The Reproductive Medicine Special Hospital of the First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一医院生殖医学专科医院,730000

出　　处：《中华生殖与避孕杂志》2019年第11期917-920,共4页Chinese Journal of Reproduction and Contraception

基　　金：甘肃省杰出青年科学基金(18JR3RA262);甘肃省自然科学基金(18JR3RA338)。

摘　　要：宫腔粘连纤维化的研究大多集中在转化生长因子-β(TGF-β)和Wnt信号通路,但这不能全面说明宫腔粘连纤维化复杂的分子机制。随着Hippo信号通路研究的不断跟进,研究表明该通路在纤维化的形成、干细胞的自我更新和分化、细胞增殖与分化的调节等方面均起到重要的作用。本文主要综述Hippo信号通路在宫腔粘连纤维化的研究现状。Most studies on intrauterine adhesion fibrosis focus on transforming growth factor-β(TGF-β)and Wnt signaling pathways,but this does not fully explain the complex molecular mechanism of intrauterine adhesion fibrosis.With the continuous follow-up of Hippo signaling pathway,it has been shown that this pathway plays an important role in the formation of fibrosis,self-renewal and differentiation of stem cells,and regulation of cell proliferation and differentiation.This article mainly describes the research status of Hippo signaling pathway in intrauterine adhesion fibrosis.

关 键 词：宫腔粘连 子宫内膜纤维化病变 Hippo信号通路 

分 类 号：R73[医药卫生—肿瘤]