Protective Effect of the Zhuang Medicine Cryptolepis buchananii Roem. et Schult. on D-GalN-induced Liver Injury in Mice  

作　　者：Chenyan LIANG Lu ZHANG Ganneng HUANG Yunli TANG Liuyan HE Li WANG Mingcheng CHEN 

机构地区：[1]Guangxi University of Chinese Medicine,Nanning 530200,China [2]Guangxi Health Technical Vocational College,Nanning 530200,China

出　　处：《Agricultural Biotechnology》2020年第1期60-62,72,共4页农业生物技术（英文版）

基　　金：Supported by The Basic Ability Improving Project of Young and Middle-aged Teachers in Guangxi(2019KY0324);Graduate Program of Guangxi University of Chinese Medicine(YCSY20190096);Collaborative Innovation Center for Zhuang and Yao Medicines(zyx[2015]-01);Sub-project of Key Laboratory of Pharmacology of Traditional Chinese Medicine(J16072);College Students’Innovation and Enterpreneurship Training Program of Guangxi University of Chinese Medicine(201910600022)

摘　　要：[Objectives] This study was conducted to study the protective effect of the Zhuang medicine Cryptolepis buchananii Roem. et Schult. on D-galactosamine(D-GalN)-induced liver injury in mice. [Methods] A mouse model of chemical liver injury was established by D-GalN, and the mice with D-GalN-induced liver injury were randomly divided into the blank group, model group, positive control group and drug-administered groups. The levels of alanine aminotransferase(ALT) and aspartate aminotransferase(AST) in the serum of the mice in each group and the levels of superoxide dismutase(SOD) and malondialdehyde(MDA) in the liver tissue of the mice were determined, and the liver pathological changes were observed. [Results] The extracts of the Zhuang medicinal herb C. buchananii could reduce the serum ALT and AST levels(P<0.05), increase the SOD content in the liver tissue of mice(P<0.05), and decrease the MDA level(P<0.05). [Conclusions] The Zhuang medicinal herb C. buchananii has a good protective effect on D-GalN-induced liver injury in mice.[Objectives] This study was conducted to study the protective effect of the Zhuang medicine Cryptolepis buchananii Roem. et Schult. on D-galactosamine(D-GalN)-induced liver injury in mice. [Methods] A mouse model of chemical liver injury was established by D-GalN, and the mice with D-GalN-induced liver injury were randomly divided into the blank group, model group, positive control group and drug-administered groups. The levels of alanine aminotransferase(ALT) and aspartate aminotransferase(AST) in the serum of the mice in each group and the levels of superoxide dismutase(SOD) and malondialdehyde(MDA) in the liver tissue of the mice were determined, and the liver pathological changes were observed. [Results] The extracts of the Zhuang medicinal herb C. buchananii could reduce the serum ALT and AST levels(P<0.05), increase the SOD content in the liver tissue of mice(P<0.05), and decrease the MDA level(P<0.05). [Conclusions] The Zhuang medicinal herb C. buchananii has a good protective effect on D-GalN-induced liver injury in mice.

关 键 词：Cryptolepis buchananii Roem.et Schult. D-GALACTOSAMINE Liver injury 

分 类 号：R29[医药卫生—民族医学]