D-GALACTOSAMINE

作品数：32被引量：125H指数：6
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相关领域：医药卫生更多>>
相关作者：邵伟王蕴玲涂植光张亚松王莹更多>>
相关机构：天津师范大学重庆医科大学第三军医大学西南医院浙江大学医学院附属第一医院更多>>
相关期刊：《Medicinal Plant》《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划福建省自然科学基金更多>>
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Gasdermin D Inhibitor Necrosulfonamide Alleviates Lipopolysaccharide/D-galactosamine-induced Acute Liver Failure in Mice被引量：6
《Journal of Clinical and Translational Hepatology》2022年第6期1148-1154,共7页Yi-Long Wu Wei-Jie Ou Ming Zhong Su Lin Yue-Yong Zhu 
Fujian Province health education joint project(No.2019-WJ-16);Natural Science Foundation of Fujian Province(No.2021J01226);Startup Fund for scientific research,Fujian Medical University(2020QH1039).
Background and Aims:Acute liver failure(ALF)is as-sociated with high mortality.Gasdermin D(GSDMD)is the executioner of pyroptosis and is involved in the patho-physiology of immune dysregulation This study investi-gate...
关键词：Liver failure ACUTE PYROPTOSIS GSDMD GSDMD-NT Necrosul-fonamide 
Sinapic acid ameliorates D-galactosamine/lipopolysaccharideinduced fulminant hepatitis in rats:Role of nuclear factor erythroidrelated factor 2/heme oxygenase-1 pathways被引量：2
《World Journal of Gastroenterology》2021年第7期592-608,共17页Mushtaq Ahmad Ansari Mohammad Raish Yousef A Bin Jardan Ajaz Ahmad Mudassar Shahid SheikhFayaz Ahmad Nazrul Haq Mohammad Rashid Khan Saleh A Bakheet 
Deanship of Scientific Research at King Saud University,No.RG-1439-083.
BACKGROUND Sinapic acid(SA)has been shown to have various pharmacological properties such as antioxidant,antifibrotic,anti-inflammatory,and anticancer activities.Its mechanism of action is dependent upon its ability t...
关键词：Sinapic acid D-galactosamine/lipopolysaccharide Oxidative stress Fulminant hepatitis ANTIOXIDANT Nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways 
Protective Activity of <i>Markhamia tomentosa</i>(Benth.) K. Schum. (Bignoniaceae) Methanol Leaves Extract against D-Galactosamine/Lipopolysaccharide-Induced Acute Liver Injury in Mice
《Journal of Biosciences and Medicines》2020年第10期74-89,共16页Roméo Joel Guemmogne Temdie Agathe Lambou Fotio Flaure Donfack Metchi Edwige Chiogo Vouffo Ymele Gilbert Thierry Nkoulou Tabi Théophile Dimo 
Markhamia tomentosa (Benth.) K. Schum. (Mt) is a Cameroonian medicinal plant, traditionally used to treat painful and inflammatory illness. This study aimed to examine the effects of methanol leaves ...
关键词：Markhamia tomentosa D-Galactosamine/Lipopolysaccharide Oxidative Stress Liver Injury 
Protective Effect of the Zhuang Medicine Cryptolepis buchananii Roem. et Schult. on D-GalN-induced Liver Injury in Mice
《Agricultural Biotechnology》2020年第1期60-62,72,共4页Chenyan LIANG Lu ZHANG Ganneng HUANG Yunli TANG Liuyan HE Li WANG Mingcheng CHEN 
Supported by The Basic Ability Improving Project of Young and Middle-aged Teachers in Guangxi(2019KY0324);Graduate Program of Guangxi University of Chinese Medicine(YCSY20190096);Collaborative Innovation Center for Zhuang and Yao Medicines(zyx[2015]-01);Sub-project of Key Laboratory of Pharmacology of Traditional Chinese Medicine(J16072);College Students’Innovation and Enterpreneurship Training Program of Guangxi University of Chinese Medicine(201910600022)
[Objectives] This study was conducted to study the protective effect of the Zhuang medicine Cryptolepis buchananii Roem. et Schult. on D-galactosamine(D-GalN)-induced liver injury in mice. [Methods] A mouse model of c...
关键词：Cryptolepis buchananii Roem.et Schult. D-GALACTOSAMINE Liver injury 
Hepatoprotective activity of Dypsis lutescens against D-galactosamine-induced hepatotoxicity in rats and its phytoconstituents
《Asian Pacific Journal of Tropical Biomedicine》2019年第11期467-473,共7页Mai M.El-Ghonemy Walaa A.El-Kashak Tahia K.Mohamed Enayat A.Omara Jihan Hussein Abdel-Razik H.Farrag Mahmoud I.Nassar Mohamed Y.El-Kady 
fund for this work has been received from the National Research Centre,Egypt(project No.11010325).
Objective:To isolate and identify the polyphenolic constituents of Dypsis lutescens,and evaluate the hepatoprotective activity of the ethanolic extract of Dypsis lutescens leaves.Methods:Hepatoprotective,antioxidant a...
关键词：Dypsis lutescens Flavonoid GLYCOSIDES Phenolic acids HEPATOPROTECTIVE Antioxidant ANTI-INFLAMMATORY 
Adiponectin receptor agonist AdipoRon relieves endotoxin-induced acute hepatitis in mice被引量：2
《Chinese Medical Journal》2019年第20期2438-2445,共8页Wen-Ze Xiao Li Zhang 
Background:Adiponectin is the most abundant adipokines that plays critical roles in the maintenance of energy homeostasis as well as inflammation regulation. The half-life of adiponectin is very short and the small-mo...
关键词：AdipoRon LIPOPOLYSACCHARIDE D-GALACTOSAMINE ACUTE HEPATITIS Apoptosis 
Protective Effects of Self-made Compound Taoren Danshen Decoction on Rats with Acute Liver Injury
《Medicinal Plant》2018年第5期107-110,共4页Yuman GUAN Kefeng ZHANG Ya GAO Jiani LI Lin ZHANG 
[Objectives] To study the protective effects of self-made Compound Taoren Danshen Decoction( CTDD) on acute liver injury induced by D-galactosamine in rats,and to explore its mechanism. [Methods]An acute liver injury ...
关键词：SELF-MADE COMPOUND Taoren DANSHEN Decoction(CTDD) D-GALACTOSAMINE Acute liver injury Oxidative stress INFLAMMATORY reaction 
Protection of plasma transfusion against lipopolysaccharide/D-galactosamine-induced fulminant hepatic failure through inhibiting apoptosis of hepatic cells in mice被引量：2
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2018年第6期436-444,共9页Bing-yu CHEN Lu-xi JIANG Ke HAO Lu WANG Ying WANG Yi-wei XIE Jian SHEN Meng-hua ZHU Xiang-ming TONG Kai-qiang LI Zhen WANG 
Project supported by the National Natural Science Foundation of China(Nos.81501824,81600595,and 81772664);the Analysis and Measurement Foundation of Zhejiang Province(No.2015C37001);the Natural Science Foundation of Zhejiang Province(Nos.LY15C090004 and LQ16H070003);the Traditional Chinese Medicine Scientific Research Foundation of Zhejiang Province(No.2014ZB007);the Traditional Chinese Medicine Outstanding Young Talent Foundation of Zhejiang Province(No.2014ZQ005);the Medicine and Health Research Foundation of Zhejiang Province(Nos.2016DTB001,2015KYA028,2014KYA233,and 2016KYB012);the Outstanding Young Scientific research Foundation of Zhejiang Province of People’s Hospital(Nos.Zry2015A005 and Zry2015B005),China
Fulminant hepatic failure is a severe clinical condition associated with extremely poor outcomes and high mortality. A number of studies have demonstrated the ability of plasma transfusion to successfully treat fulmin...
关键词：Fulminant hepatic failure PLASMA Inflammation APOPTOSIS 
Novel D-galactosamine-induced cynomolgus monkey model of acute liver failure被引量：5
《World Journal of Gastroenterology》2017年第42期7572-7583,共12页Lei Feng Lei Cai Guo-Lin He Jun Weng Yang Li Ming-Xin Pan Ze-Sheng Jiang Qing Peng Yi Gao 
Supported by The National Natural Science Foundation of China,No.81470875;The Natural Science Foundation of Guangdong Province,China,No.2014A030312013;The Science and Technology Planning Project of Guangdong Province,China,No.2014B020227002,No.2015B090903069,and No.2015B020229002;The Science and Technology Program of Guangzhou,China,No.201604020002
AIM To establish a simplified, reproducible D-galactosamineinduced cynomolgus monkey model of acute liver failure having an appropriate treatment window. METHODS Sixteen cynomolgus monkeys were randomly dividedinto fo...
关键词：Cynomolgus monkey D-GALACTOSAMINE Acute liver failure Artificial liver support systems Intracranial pressure 
Establishment of a new acute-on-chronic liver failure model被引量：6
《Acta Pharmaceutica Sinica B》2017年第3期326-333,共8页Fangfang Li Luyang Miao Hua Sun Yuyang Zhang Xiuqi Bao Dan Zhang 
supported by 863 program(No.2014AA021101)from National High-tech R&D Program of China;the grants from National Sciences Foundation of China(Grant No.81573487)
To establish an animal model of acute-on-chronic liver failure(ACLF) that would replicate the pathological process of ACLF in humans, rats were administered porcine serum(PS) for 11 weeks. Liver fibrosis was determine...
关键词：ACLF D-GALACTOSAMINE FIBROSIS LIPOPOLYSACCHARIDE Porcine serum RAT 
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