多系统萎缩心血管自主神经功能障碍的临床研究  

Clinical study of cardiovascular autonomic nervous dysfunction in patients with multiple system atrophy

作　　者：贺姣 卢宏[1] 彭涛[1] 余列[1] 刘希[1] 胡文涛[1] 田田[1] 籍炀飞[1] 孙桂芳[1] 刘艳茹 赵然[1] 王景涛[1] HE Jiao;LU Hong;PENG Tao;YU Lie;LIU Xi;HU Wentao;TIAN Tian;JI Yangfei;SUN Guifang;LIU Yanru;ZHAO Ran;WANG Jingtao(Department of Neurology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院神经内科

出　　处：《中国神经精神疾病杂志》2019年第12期725-728,共4页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的分析多系统萎缩(multiple system atrophy,MSA)患者心血管自主神经功能障碍的情况。方法纳入88例多系统萎缩患者作为研究对象,并选择年龄、性别相匹配的体检的88例健康者作为对照组。比较两组动态血压及动态心电图相关参数的差异。结果MSA组动态血压中的夜间收缩压(nocturnal systolic blood pressure,nSBP)、夜间舒张压(nocturnal diastolic blood pressure,nDBP)较对照组明显升高(P均<0.05);每5 min R-R间期标准差均值(mean of the standard deviations of all 5-min normal-to-normal R-R intervals of the entire recording,SDNN Index)、行低频成分(low frequency,LF)、高频成分(high frequency,HF)等三个参数中MSA组较健康对照组参数水平明显降低,差异有统计学意义(P<0.05)。结论研究多系统萎缩患者心血管自主神经障碍的临床特点,对MSA患者的诊断具有参考意义。Objective To analyze the cardiovascular autonomic dysfunction in patients with multisystem atrophy(MSA).Methods Eighty-eight patients with multiple system atrophy from our hospital from January 2015 to April 2019 were selected as MSA group,and another 88 healthy persons matched with the age and sex were selected as control group.The parameters of ambulatory blood pressure and autonomic nervous function were compared between the two groups.Results The nocturnal systolic blood pressure(nSBP)and nocturnal diastolic blood pressure(nDBP)in MSA group were significantly higher than those in control group(P<0.05).The mean of the standard deviations of all 5-min normal-to-normal R-R intervals of the entire recording,low frequency power and high frequency power in MSA group were significantly lower than those in healthy control group(P<0.05).Conclusion The clinical features of cardiovascular autonomic nerve disorders are helpful for the diagnosis of MSA.

关 键 词：多系统萎缩 动态血压 动态心电图 自主神经功能障碍 

分 类 号：R741[医药卫生—神经病学与精神病学] R541.9[医药卫生—临床医学]