白血病髓外浸润前微环境改变的研究进展  

Advances in changes of microenvironment before leukemic extramedullary infiltration

作　　者：王丽兰[1] 刘莲清 申政磊[1] WANG Lilan;LIU Lianqing;SHEN Zhenglei(Department of Hematology,the Third Affiliated Hospital of Kunming Medical University,Kunming,Yunnan 650100,China)

机构地区：[1]昆明医科大学第三附属医院血液科

出　　处：《重庆医学》2020年第2期306-309,314,共5页Chongqing medicine

基　　金：国家自然科学基金项目（81360089）;云南省科技厅应用基础研究[2015FB072,2017FE468（-204）];云南省教育厅项目（2018JS229）

摘　　要：肿瘤转移是肿瘤细胞及其分泌的各种因子和宿主细胞间发生一系列相互作用的复杂过程,这些因子通过多种复杂的机制在特定器官中形成一个适合原发肿瘤生长繁殖的转移前微环境促进肿瘤转移。这一理论在白血病中同样存在,白血病常发生脾脏、颅脑、睾丸、淋巴结等髓外部位,这些浸润部位在转移前其微环境会发生骨髓来源细胞招募、血管通透性增加、慢性炎症等适应性的变化,为循环中的白血病细胞提供适宜的生存环境,但具体的机制尚不能阐述。现就白血病髓外浸润部位微环境改变的研究进展作一综述,以期提高白血病的治疗及预后。Tumor metastasis is a complex process of a series of interactions among tumor cells,various factors and host cells,these factors through a variety of complex mechanism formed in specific organs to grow for a primary tumor before the transfer of microenvironment to promote tumor metastasis.This theory also exists in leukemia,leukemia often occurs in the spleen,brain,testis,lymph nodes and other pulp external potential infiltration,the microenvironment of these infiltrating sites has undergone adaptive changes such as bone marrow-derived cell recruitment,increased vascular permeability,and chronic inflammation before metastasis,so as to provide an appropriate living environment for circulating leukemia cells,but the specific mechanism is not elaboration.This article reviews the research progress of the microenvironment changes in the infiltration site of leukemia extramedullary infiltration,in order to improve the treatment and prognosis of leukemia.

关 键 词：肿瘤 肿瘤微环境 白血病 分泌因子 

分 类 号：R733.7[医药卫生—肿瘤]