连接斑株蛋白在肿瘤发生、发展中作用的研究进展  

Advances in the role of junction plakoglobin in tumorigenesis

作　　者：肖莉(综述) 房娟[2] 刘英(审校) XIAO Li;FANG Juan;LIU Ying(School of Stomatology,North Sichuan Medical College,Nanchong,Sichuan 637000,China;Guanghua Stomatological College of Sun Yat-sen University and the Affiliated Stomatological Hospital of Sun Yat-sen University/Guangdong Provincial Key Laboratory of Stomatology,Guangzhou,Guangdong 510000,China)

机构地区：[1]川北医学院口腔医学系,四川南充637000 [2]中山大学光华口腔医学院附属口腔医院/广东省口腔医学重点实验室,广州510000

出　　处：《重庆医学》2020年第2期319-323,共5页Chongqing medicine

基　　金：广东省口腔医学重点实验室科研项目（KF2016120103）;川北医学院博士启动基金项目（CBY13-QD-07）

摘　　要：连接斑株蛋白(JUP)是犰狳蛋白质家族的成员,与β-连环蛋白(β-catenin)同源。一方面,作为黏附连接和桥粒的主要成分,JUP主要在细胞与细胞间的连接中发挥重要作用。另一方面,作为β-catenin的同源蛋白,JUP参与Wnt通路,在调节细胞生物学功能方面起着至关重要的作用。JUP在肿瘤发生、发展中到底发挥抑制作用还是促进作用,是近年来研究的热点。因此,深入研究JUP在肿瘤发生、发展、转移中的作用及靶向治疗具有重要意义。Junction plakoglobin(JUP),a homolog of beta-catenin(β-catenin),is a member of the armadillo family of proteins.On the one hand,as a major component of adhesion junctions and desmosomes,JUP plays an important role in cell-cell junctions.On the other hand,as a homologous protein ofβ-catenin,JUP involves in Wnt pathway and plays a crucial role in regulating biological functions of cells.In recent years,whether JUP plays an inhibitory or promoting role in tumorigenesis has become a hot topic.Therefore,it is of great significance to further study the role of JUP in development,metastasis and targeted therapy of cancer.

关 键 词：桥粒斑蛋白质类 Β连环素 肿瘤 细胞运动 肿瘤侵润 

分 类 号：R730.2[医药卫生—肿瘤]