TGR5受体介导的信号转导通路的研究进展  

Research progress of signaling transduction pathway mediated by TGR5

作　　者：祁有朝[1] 李培锋[1] QI You-chao;LI Pei-feng(College of Veterinary Medicine,Key Lab of Clinical Diagnosis and Treatment Techniques for Animal Disease,Ministry of Agriculture,Hohhot 010018,China)

机构地区：[1]内蒙古农业大学兽医学院,农业部动物临床诊疗技术重点实验室,内蒙古呼和浩特010018

出　　处：《中国药理学通报》2020年第2期153-157,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金面上资助项目(No 31272605)。

摘　　要：GPCBAR1也称作TGR5受体,是GPCRs家族成员之一。TGR5受体在人类和动物体内广泛的表达,是一种位于细胞膜的模式识别受体,在抗炎免疫调节、能量代谢、葡萄糖代谢、抗癌等方面都具有十分重要的作用。配体一旦激活TGR5受体,介导一系列信号通路,从而发挥不同的生物学效应。本文就AKT信号通路、NF-κB信号通路、ERK信号通路、STAT3信号通路、cAMP信号通路、TGR5受体介导信号通路的研究方法与研究成果,以及TGR5受体介导信号转导通路研究与新药开发展开综述。GPCBAR1,also known as TGR5 receptor,is one member of the GPCRs family.TGR5,a pattern recognition receptor located on cell membrane,is widely expressed in human beings and animals,playing numerous significant roles in anti-inflammation and immune regulation,energy metabolism,glucose metabolism and anti-cancer.Many signaling pathways are induced by TGR5 upon activated.AKT,NF-κB,ERK,STAT3,cAMP signaling pathways,methods and results of TGR5-mediated signaling pathways and the development of new drugs via TGR5-mediated signaling pathways were reviewed in this paper.

关 键 词：TGR5 AKT NF-κB ERK STAT3 CAMP 

分 类 号：R-05[医药卫生] R329.25