Swiprosin-1/EFhd2调控免疫炎症反应的研究进展  

Role of Swiprosin-1/EFhd2 in regulating immune inflammatory response

作　　者：冯美霞 苏笠 王志斌 张立超[1] FENG Mei-xia;SU Li;WANG Zhi-bin;ZHANG Li-chao(Dept of Pharmacy,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai 200071,China;Translational Medicine Research Institute of Shanghai University,Shanghai 200444,China;Dept of Pharmacy,Second Milltary Medical University,Shanghai 200433,China)

机构地区：[1]上海市中医医院药剂科,上海200071 [2]上海大学转化医学研究院,上海200444 [3]第二军医大学药学系,上海200433

出　　处：《中国药理学通报》2020年第2期162-166,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81872880)。

摘　　要：Swiprosin-1(也称为EFhd2)是最早在T淋巴细胞中发现的一种衔接蛋白。研究发现,其在巨噬细胞、B淋巴细胞、肥大细胞等其它多种免疫细胞上也表达,并且影响免疫细胞的激活、迁移、凋亡及炎症反应,参与NF-κB、JAK-STAT、MAPK和钙信号等信号通路。该文简要综述了近年来报道的EFhd2在免疫炎症反应调节中的作用和机制,为进一步明确EFhd2作为新的免疫调控潜在靶点提供理论依据。Swiprosin-1(also known as EFhd2)is one of the earliest adaptor proteins found in T lymphocytes.Subsequent studies have found that it is also expressed on macrophages,B lymphocytes,mast cells and other immune cells,and affects the activation,migration,apoptosis and inflammatory response of immune cells,and participates in many signaling pathways such as NF-κB,JAK-STAT,MAPK and calcium signaling.This article briefly reviews the role and mechanism of EFhd2 reported in the regulation of immune inflammatory response in recent years,and provides a theoretical basis for further clarifying EFhd2 as a potential target for new immune regulation.

关 键 词：EFhd2 免疫炎症 NF-ΚB JAK-STAT MAPK 钙信号 细胞迁移 

分 类 号：R329.25[医药卫生—人体解剖和组织胚胎学] R341[医药卫生—基础医学]