早期急性脑梗死合并2型糖尿病患者溶栓治疗后使用胰岛素泵进行强化治疗的临床观察  

Clinical observation of intensive treatment with insulin pump after thrombolysis in patients with early acute cerebral infarction and type 2 diabetes mellitus

作　　者：陈亮[1] 丁桂兵[1] 吴晋[1] CHEN Liang;DING Guibing;WU Jin(Department of Neurology,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210003,China)

机构地区：[1]南京医科大学第二附属医院神经内科

出　　处：《中国医药科学》2019年第24期237-240,共4页China Medicine And Pharmacy

摘　　要：目的探讨早期急性脑梗死合并2型糖尿病的患者溶栓治疗术后进行血糖控制的最佳治疗方案。方法将我院2016年2月~2018年12月因早期急性脑梗死行溶栓治疗的2型糖尿病48例患者,根据随机数字表法分为胰岛素泵组(P组)和对照组(C组),P组术后应用胰岛素泵进行持续胰岛素皮下注射,C组根据血糖检测结果行间断皮下注射胰岛素。比较两组患者术后血糖控制的情况、高血糖和低血糖的发生率及术后NIHSS评分。结果P组血糖的可控性明显优于C组,高血糖和低血糖的发生率明显低于C组,术后14d的NIHSS评分明显低于C组(P<0.05),两组术后90dNIHSS评分无统计学差异(P>0.05)。结论早期急性脑梗死合并2型糖尿病患者溶栓治疗后使用胰岛素泵持续皮下输注胰岛素可以快速、有效、安全、经济的控制血糖,效果优于间断皮下注射胰岛素。Objective To explore the best treatment option for blood glucose control after thrombolysis in patients with early acute cerebral infarction and type 2 diabetes mellitus.Methods A total of 48 patients with type 2 diabetes treated in our hospital from February 2016 to December 2018 were divided into insulin pump group(group P)and control group(group C).The blood glucose control,incidence of hyperglycemia and hypoglycemia and postoperative National Institutes of Health Stroke Scale(NIHSS)score were compared between the two groups.Results The continence of blood glucose in group P was significantly better than group C,the incidence of hyperglycemia and hypoglycemia was significantly lower than group C,and the NIHSS score at 14 days after surgery was significantly lower than that of group C(P<0.05),without any difference in NIHSS score at 90 days between the two groups(P>0.05).Conclusion The application of insulin pump for patients with early acute cerebral infarction and type 2 diabetes mellitus after thrombolysis can control blood glucose quickly,effectively,safely and economically,and the effect is better than that of intermittent subcutaneous insulin injection.

关 键 词：早期急性脑梗死 2型糖尿病 溶栓治疗 胰岛素泵 血糖 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R587.1[医药卫生—临床医学]