精神分裂症认知损害动物模型的研究现状  

Current status of research concerning animal models of cognitive impairment of schizophrenia

作　　者：刘鑫垚 马超[1,2] 贾竑晓[1,2] Liu Xinyao;Ma Chao;Jia Hongxiao(The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders,Beijing Anding Hospital,Capital Medical University,Beijing 100088,China;Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学附属北京安定医院国家精神心理疾病临床研究中心精神疾病诊断与治疗北京市重点实验室,北京100088 [2]首都医科大学人脑保护高精尖创新中心,北京100069

出　　处：《首都医科大学学报》2020年第1期50-54,共5页Journal of Capital Medical University

基　　金：国家自然科学基金(81873398,81904120);首都卫生发展科研专项重点攻关项目(2018-1-2122);北京中医药科技发展基金青年项目(QN2018-27);北京市医院管理中心“登峰”计划(DFL20191901)~~

摘　　要：精神分裂症的病因尚未明确,认知损害是治疗精神分裂症治疗的难点和热点。因此建立可靠、可预测的认知损害动物模型,可以增加对该疾病相关神经生物学机制的了解,有助于开发针对认知损害的有效药物。本文将围绕药理学、神经发育和基因3个方面综述精神分裂症认知损害动物模型研究进展,旨在为理解和治疗精神分裂症的认知损害提供新的思路。The mechanism of schizophrenia is not yet precise.Cognitive impairment is a difficult point in the treatment of schizophrenia.Reliable and predictable animal models could improve understanding of the neurobiological basis of the disease,and also is crucial for developing new drugs that work better.This review will focus on pharmacological models,neurodevelopmental models and genetic models and provides ideas for studying and alleviating the cognitive impairment of schizophrenia.

关 键 词：精神分裂症 动物模型 认知 

分 类 号：R749.3[医药卫生—神经病学与精神病学]