中性粒细胞与淋巴细胞比值对胰腺腺癌根治术后患者的预后评估  

Prognostic evaluation of ratio of neutrophils to lymphocytes in patients with pancreatic adenocarcinoma after radical resection

作　　者：张凤萍 高志强[1] 陈德华 马雪松 申鹏程 唐哲[1] Zhang Fengping;Gao Zhiqiang;Chen Dehua;Ma Xuesong;Shen Pengcheng;Tang Zhe(Department of Hepatobiliary Pancreatic Surgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院肝胆胰外科

出　　处：《河南外科学杂志》2020年第1期7-10,共4页Henan Journal of Surgery

摘　　要：目的探讨中性粒细胞计数与淋巴细胞计数比(NLR)对胰腺腺癌根治术后患者预后的评估价值。方法回顾性分析郑州大学第一附属医院肝胆胰外科行胰腺癌根治术的77例患者的临床资料,通过术前的血常规结果计算出NLR值,取NLR中位数2.63为截点将患者分为高NLR和低NLR 2组。比较2组患者术后第1年、第3年的生存率,并分别对其影响因素进行分析。结果低NLR组第1年、第3年的生存率分别为89.2%、40.5%,均高于高NLR组的65.7%、11.4%,差异有统计学意义(P<0.05);单因素及多因素分析提示NLR为胰腺癌根治术后患者预后的影响因素(P<0.05)。结论外周血高NLR是一个提示胰腺癌预后较差的指标。Objective The aim of the study was to evaluate the prognostic value of neutrophil count and lymphocyte count ratio(neutrophil-to-lymphocyte ratio, NLR) in patients with pancreatic adenocarcinoma after radical resection.Methods The clinical records of 77 patients undergoing radical resection of pancreatic cancer in the Department of Hepatobiliary and Pancreatic surgery in the first affiliated Hospital of Zhengzhou University were retrospectively analyzed. The NLR values were calculated by blood routine before operation. The patients were divided into two groups at the median of NLR 2.63. The 1-year and 3-year survival rates of the two groups were compared and the influencing factors were analyzed.Results The 1-year and 3-year survival rates in NLR group were 89.2% and 40.5, respectively, which were higher than those of high NLR group(65.7%, 11.4%, P<0.05). Univariate and multivariate analysis showed that NLR was a prognostic factor in patients with pancreatic cancer after radical resection(P<0.05).Conclusion High NLR in peripheral blood is an indicator of poor prognosis for pancreatic cancer.

关 键 词：胰腺癌 手术切除 NLR 预后分析 

分 类 号：R735.9[医药卫生—肿瘤]