银杏内酯联合阿替普酶静脉溶栓治疗大动脉粥样硬化性缺血性脑卒中的临床疗效  

Clinical efficacy of ginkgolides+rt-PA intravenous thrombolysis in the treatment of aortic atherosclerotic stroke

作　　者：李海健[1] 于振华 王宝华[2] 于春华 Li Haijian;Yu Zhenhua;Wang Baohua;Yu Chunhua(Department of Neurology,The Affiliated Hospital of Qingdao University,Qingdao 266000,China;Department of Neurology,Haiyang People’s Hospital,Haiyang 265100,China)

机构地区：[1]青岛大学附属医院神经内科,266000 [2]海阳市人民医院神经内科,265100

出　　处：《国际医药卫生导报》2020年第1期17-19,119,共4页International Medicine and Health Guidance News

基　　金：山东省自然科学基金面上项目(ZR2016HM29)。

摘　　要：目的观察银杏内酯+阿替普酶(rt-PA)静脉溶栓治疗大动脉粥样硬化性缺血性脑卒中(CIS)的临床疗效。方法选取2017年2月至2019年3月本院及海阳市人民医院84例大动脉粥样硬化性CIS患者,按照治疗方法分组,各42例。对照组予以rt-PA静脉溶栓治疗,观察组在rt-PA静脉溶栓基础上予以银杏内酯治疗。对比两组临床疗效、不良反应发生率、治疗前、治疗14 d后美国国立卫生研究院卒中量表(NIHSS)评分、改良Rankin量表(mRS)评分、凝血酶时间(TT)、凝血酶原时间(PT)、纤维蛋白原(FIB)。结果观察组治疗总有效率较对照组高[88.10%(37/42)比69.05%(29/42)],两组比较差异有统计学意义(P<0.05);治疗14 d后观察组NIHSS评分、mRS评分较对照组低(P<0.05);治疗14 d后观察组TT、PT、FIB较对照组低(P<0.05);观察组不良反应发生率与对照组比较差异无统计学意义[16.67%(7/42)比7.14%(3/42),P>0.05]。结论银杏内酯+rt-PA静脉溶栓治疗大动脉粥样硬化性CIS,疗效显著,可改善患者凝血状态,加快患者神经功能恢复,并具有较高的安全性。Objective To observe the clinical efficacy of ginkgolides+alteplase(rt-PA)intravenous thrombolysis in the treatment of aortic atherosclerotic cerebral ischemic stroke(CIS).Methods Eighty-four patients with aortic atherosclerotic CIS were enrolled in our hospital from February 2017 to March 2019,and they were divided into two groups according to the treatment methods,42 cases in each group.The control group was treated with rt-PA intravenous thrombolysis,and the observation group was treated with ginkgolides on the basis of rt-PA intravenous thrombolysis.The clinical efficacy,the incidence of adverse reactions,NIHSS score,modified Rankin scale(mRS)score,thrombin time(TT),prothrombin time(PT),fibrinogen(FIB)before treatment and after 14 days of treatment were compared.Results The total effective rate of the observation group was 88.10%(37/42),which was higher than that of the control group[69.05%(29/42)](P<0.05).After 14 days of treatment,the NIHSS score and mRS score of the observation group were lower than those of the control group,the levels of TT,PT,and FIB in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was 16.67%(7/42),there was no statistically significant difference compared with 7.14%(3/42)in the control group(P>0.05).Conclusion Ginkgolides+rt-PA intravenous thrombolysis is effective in the treatment of aortic atherosclerotic CIS,which can improve the coagulation status of patients,accelerate the recovery of neurological function,and has high safety.

关 键 词：大动脉粥样硬化 缺血性脑卒中 银杏内酯 阿替普酶 静脉溶栓 

分 类 号：R74[医药卫生—神经病学与精神病学]