14-3-3蛋白在胃癌中的作用及机制研究进展  

Progress of effects of 14-3-3 protein on gastric cancer and its mechanism

作　　者：李易桐 付琰 张雅婷[1,2] 翁乾淋 李玉民 Li Yi-Tong;Fu Yan;Zhang Ya-Ting;Weng Qian-Ling;Li Yu-Min(Second Clinical Medical College of Lanzhou University,Lanzhou 730030,China;Key Laboratory of Digestive System Tumors of Gansu Province,Lanzhou730000,China;Department of Oncology,Second Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第二临床医学院,兰州730030 [2]甘肃省消化肿瘤重点实验室,兰州730000 [3]兰州大学第二医院肿瘤外科,兰州730000

出　　处：《解放军医学杂志》2020年第1期97-101,共5页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金面上项目(31770537,81572437);甘肃省科技计划项目(18YF1WA113);兰州大学第二医院“萃英学子科研培育”计划~~

摘　　要：14-3-3蛋白是一类高度保守的细胞蛋白家族,在所有真核生物中广泛表达。它可与多种功能信号蛋白结合,因此又被称为蛋白相互作用的“桥梁蛋白”。研究表明,14-3-3蛋白家族在恶性肿瘤中的表达水平与肿瘤大小、浸润深度、转移情况等密切相关。同时,有研究表明,14-3-3蛋白在胃癌的细胞信号传递、细胞周期进程控制、细胞凋亡调控中起关键作用,在胃癌的发生发展、增殖浸润、预后耐药等环节发挥作用,有望成为胃癌治疗的新靶点。该文就14-3-3蛋白在胃癌中的作用及相关机制进行综述。14-3-3 proteins are a highly conserved family of cellular proteins, and widely expressed in all eukaryotes. Because they can bind to a variety of functional signal proteins, so be regarded as "bridge proteins" in protein interaction. Studies have shown that the expression level of 14-3-3 protein family in malignant tumors is closely related to tumor size, depth of invasion and metastasis. Some other studies have shown that 14-3-3 protein plays a pivotal role in cell signal transduction, control of cell cycle process and regulation of apoptosis, and plays an important role in the development of gastric cancer, proliferation, invasion, prognosis and drug resistance, so is expected to become a novel therapeutic target for gastric cancer. The present paper aims to expound the role and relevant mechanisms of 14-3-3 protein in gastric cancer.

关 键 词：14-3-3蛋白 胃癌 亚型 研究进展 

分 类 号：R735.2[医药卫生—肿瘤]