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作 者:高亮 许玉洁[1,2,3,4] 陈进林 梅承芳 陈桂兰[1,2,3,4] 霍嘉维 刘桃妹[1,2,3,4] 冯宝欣 余明喧[1,2,3,4] 曾国驱 GAO Liang;XU Yujie;CHEN Jinlin;MEI Chengfang;CHEN Guilan;HUO Jiawei;LIU Taomei;FENG Baoxin;YU Mingxuan;ZENG Guoqu(Guangdong Institute of Microbiology,Guangdong Academy of Sciences,Guangzhou 510070;State Key Laboratory of Applied Microbiology Southern China,Guangzhou 510070;Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application,Guangzhou 510070;Guangdong Open Laboratory of Applied Microbiology,Guangzhou 510070)
机构地区:[1]广东省科学院,广东省微生物研究所,广州510070 [2]华南应用微生物国家重点实验室,广州510070 [3]广东省菌种保藏与应用重点实验室,广州510070 [4]广东省微生物应用新技术公共实验室,广州510070
出 处:《环境科学学报》2020年第2期734-740,共7页Acta Scientiae Circumstantiae
基 金:广州市科技计划项目(No.201707010162);广东省重点领域研发计划(No.2019B110205004)
摘 要:随着非甾体抗炎药(NSAIDs)的持续使用与排放,世界各地的地表水、海水、地下水、污水厂进出水中均已频繁检测到该类药物,这对生态系统中各种非靶标生物造成了一定威胁.本研究评价了两种典型的非甾体抗炎药-双氯芬酸(Diclofenac)和醋氨酚(Acetaminophen)对中国特有物种稀有鮈鲫(Gobiocypris rarus)早期生活阶段的毒性效应.实验结果显示,醋氨酚的毒性较弱,当浓度达到48.4 mg·L^-1(NOEC)时,稀有鮈鲫的孵化率、死亡率、异常率、全长和干重均未表现出明显的中毒症状;而双氯酚酸的毒性则较强,当浓度达17.8 mg·L^-1(LC10)时,即可导致稀有鮈鲫孵化率下降,当浓度达到10.2 mg·L^-1(LOEC)时,即可造成幼鱼外观和行为的显著异常,表明双氯芬酸对稀有鮈鲫的孵化和生长均产生了一定的致毒效应.同时,根据稀有鮈鲫和几种常用模式生物之间的孵化率、孵化后存活率、体长和双氯芬酸敏感性的比较结果,可认为稀有鮈鲫适用于污染物对鱼类早期生活阶段毒性效应的评估.Due to the continuous use and emission, the nonsteroidal anti-inflammatory drugs(NSAIDs) have been frequently detected in the natural surface water, seawater, groundwater and the inlet and outlet water of sewage treatment plants, which has posed a threat to a variety of non-target organisms in the ecosystem. In this study, we evaluated the toxicity of two typical NSAIDs, acetaminophenand diclofenac, on the early-life stage of Chinese Rare Minnow(Gobiocypris rarus), a Chinese endemic species. No significant toxic effect on the hatching rate, mortality, abnormal rate, total length and dry weight of Rare Minnow was observed when the acetaminophen concentration increased from 0 to 48.4 mg·L^-1. In contrast, diclofenac caused a significant decrease in the hatching rate of Rare Minnow at the concentration of 17.8 mg·L^-1(LC10). The lowest observed effective concentration(LOEC) that caused abnormal appearance and behavior of larvae was 10.2 mg·L^-1, indicating that diclofenac had significant toxicity on the hatching and growth of the fish. By comparing the hatching rate, survival rate post-hatching, body length and sensitivity to diclofenac of Chinese Rare Minnow and several other model organisms, Chinese Rare Minnow could be considered to be a new model organism for evaluating the early-life stage toxicity of aquatic pollutants to fish.
关 键 词:非甾体抗炎药 双氯芬酸 醋氨酚 稀有鮈鲫 鱼类早期生活阶段毒性试验
分 类 号:X171.5[环境科学与工程—环境科学]
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