控制营养状态评分评估根治性胃癌切除术患者预后的临床价值  

Clinical value of controlling nutritional status score in evaluating prognosis in patients with gastric cancer radical resection

作　　者：赵珅[1] 黄峰[2] 林榕波[1] ZHAO Shen;HUANG Feng;LIN Rongbo(Department of Abdominal Oncology,Fujian Provincial Tumor Hospital/Tumor Hospital Affiliated to Fujian Medical University,Fuzhou,Fujian 350014,China;Department of General Surgery,Fujian Provincial Tumor Hospital/Tumor Hospital Affiliated to Fujian Medical University,Fuzhou,Fujian 350014,China)

机构地区：[1]福建省肿瘤医院/福建医科大学附属肿瘤医院腹部肿瘤科,福建福州350014 [2]福建省肿瘤医院/福建医科大学附属肿瘤医院普外科,福建福州350014

出　　处：《检验医学与临床》2020年第4期444-446,451,共4页Laboratory Medicine and Clinic

基　　金：福建省自然科学基金项目(2018J01271)

摘　　要：目的评估术前控制营养状态(CONUT)评分与根治性胃癌切除术患者临床预后的关系。方法回顾性分析2011年2月至2013年12月行根治性胃癌切除术的231例患者,评估每例患者的CONUT评分,根据CONUT评分将所有患者分为高CONUT评分组(CONUT评分≥3分,n=64)和低CONUT评分组(CONUT评分<3分,n=167)。采用Kaplan-Meier曲线评价两组患者5年无病生存率(DFS)差异。采用COX回归评价5年DFS的独立危险因子。结果高CONUT评分组患者5年DFS较低CONUT评分组明显降低(46.9%vs.71.3%,P=0.001)。多因素COX回归分析显示,TNM分期(HR:1.524,95%CI:1.162~1.998,P=0.002)、CONUT评分(HR:1.997,95%CI:1.283~3.108,P=0.002)是5年DFS的独立危险因子。结论术前CONUT评分是评估根治性胃癌切除术患者预后的潜在指标之一,术前高CONUT评分往往提示患者预后不佳。Objective To investigate the relationship between the preoperative controlling nutritional status(CONUT)score and clinical prognosis in the patients with gastric cancer radical resection.Methods A total of 231 patients with gastric cancer radical resection from February 2011 to December 2013 were retrospectively analyzed.The CONUT score in each case was evaluated.All cases were divided into the high CONUT score group(CONUT score≥3 points,n=64)and low CONUT score group(CONUT score<3 points,n=167)according to the CONUT score.The difference of 5-year disease-free survival(DFS)rate in the two groups was assessed by adopting the Kaplan-Meier curves.The independent risk factors for 5-year DFS were assessed by adopting the COX regression.Results The 5 year DFS in the high CONUT score group was significantly decreased compared with the low CONUT score group(46.9%vs.71.3%,P=0.001).The multivariate COX regression demonstrated that the TNM stage(HR:1.524,95%CI:1.162-1.998,P=0.002)and CONUT score(HR:1.997,95%CI:1.283-3.108,P=0.002)were the independent risk factors of 5-year DFS.Conclusion The preoperative CONUT score is one of latent indicators for evaluating the prognosis in the patients with gastric cancer radical resection.The high preoperative CONUT score frequently prompts the poor prognosis of the patients.

关 键 词：胃癌 控制营养状态评分 无病生存率 预后 

分 类 号：R735.2[医药卫生—肿瘤]