MoCA北京版和MMSE评估老年缺血性脑白质病变患者认知障碍的分析  

Evaluation of cognitive impairment by Mo CA Beijing Version and MMSE in elderly patients with ischemic leukoencephalopathy

作　　者：李见[1] 李长青[1] 刘东涛[1] 周立春[1] LI Jian;LI Changqing;LIU Dongtao(Department of Neurology,Affiliated Beijing Chaoyang Hospital of Capital Medical University,Beijing 100043,China)

机构地区：[1]首都医科大学附属北京朝阳医院京西院区神经内科

出　　处：《中风与神经疾病杂志》2019年第11期982-986,共5页Journal of Apoplexy and Nervous Diseases

基　　金：首都医科大学科研培育基金资助项目(No.CYYPY201818);国家自然科学基金资助项目(81671126)

摘　　要：目的探讨北京地区缺血性脑白质病变患者认知功能障碍的特点,发现简易精神状态量表(minimental state examination,MMSE)和蒙特利尔认知评估北京版(Montreal cognitive assessment Beijing Version,MoCA北京版)量表在缺血性脑白质病变患者认知功能障碍中的应用价值。方法选择2013年1月~2019年10月北京朝阳医院的184例脑白质病变患者作为实验组,同期体检未发生缺血性脑白病变的92例正常老年人为对照组,采用MMSE、MoCA北京版评估两组认知功能状态。结果实验组MMSE评分与对照组相比差异无统计学意义(P>0.05),实验组MoCA北京版评分两组差异具有统计学意义(P<0.05)。MoCA北京版实验组患者视空间与执行功能、抽象、延迟回忆评分均低于对照组(P<0.05)。结论MoCA北京版对认知障碍的检出率大于MMSE,缺血性脑白质病变患者在语言、视空间与执行功能、抽象功能、延迟回忆、信息加工处理速度等多种认知领域受损。MoCA北京版可作为缺血性脑白质病变患者认知障碍的有效筛查工具。Objective To investigate the characteristics of cognitive impairment and evaluation value of mini-mental state examination(MMSE)and Montreal cognitive assessment Beijing Version(MoCA Beijing Version)in patients with ischemic white matter lesions in Beijing.Methods A total of 184 patients with ischemic leukoencephalopathy admitted during January 2013 to October 2019 in Beijing Chaoyang Hospital were selected as the observation group,while 92 normal elderly people without ischemic leukoencephalopathy in the same period were selected as the control group.MMSE and MoCA Beijing Version were used to evaluate the cognitive function of the two groups.Results There was no significant difference in MMSE score between the experimental group and the control group(P>0.05),the total score of MoCA Beijing between the two groups was statistically significant(P<0.05),the visual space,executive function,abstract and delayed recall scores of MoCA were lower than those of the control group(P<0.05).Conclusion The detection rate of cognitive impairment by MoCA Beijing version was higher than that of MMSE.Patients with ischemic leukoencephalopathy were impaired in many cognitive domains,such as language,visual spatial ability and executive function,abstract thinking,delayed recall fluency and the speed of information processing.MoCA Beijing version was an effective screening means for ischemic leukoencephalopathy patients with cognitive impairment.

关 键 词：MoCA北京版 MMSE 缺血性脑白质病变 认知功能障碍 

分 类 号：R749.13[医药卫生—神经病学与精神病学]