SIRT6通过抑制JAK2/STAT3信号通路抑制胃癌生长  

SIRT6 Inhibits the Growth of Gastric Cancer by Inhibiting JAK2/STAT3 Signaling Pathway

作　　者：朱秀敏[1] Zhu Xiumin(Henan Nursing Vocational College,Anyang,455000)

机构地区：[1]河南护理职业学院

出　　处：《基因组学与应用生物学》2019年第11期5215-5220,共6页Genomics and Applied Biology

摘　　要：本研究旨在通过SIRT6对表达和生物功能信号通路的抑制作用来研究其对胃癌(GC)生长的影响。通过体内实验本研究对SIRT6在胃癌组织和细胞系中的表达水平降低的原因与其在BGC823和SGC7901细胞中过表达中抑制GC细胞的活性和增殖的机理进行了研究。SIRT6在SGC7901中的过表达抑制了裸鼠细胞中SGC7901细胞的生长。同时,GC组织的IHC染色显示,当p-STAT3在GC组织中的表达水平提高时,SIRT6在GC组织中的表达水平降低。高SIRT6水平的GC组织中p-STAT3表达非常低。本研究表明,SIRT6阻断了JAK2/STAT3的活化作用并抑制了JAK2/STAT3信号通路的下游目标D1和Bcl2的表达。This paper focuses on the effects of SIRT6 on the growth of gastric cancer(GC)by inhibiting the expression and signaling pathways of biological function.The causes of SIRT6 expression in gastric cancer tissue and cell lines were studied in vivo and the mechanism of inhibition of activity and proliferation of GC cells in BGC823 and SGC7901 cells was investigated.The over-expression of SIRT6 in SGC7901 inhibited the growth of SGC7901 cells in nude mouse cells.At the same time,the IHC staining of GC tissue showed that the expression level of SIRT6 in GC tissue decreased when the expression level of P-STAT3 in GC was increased.The P-STAT3 expression at high SIRT6 level in GC tissue was very low.It was indicated that SIRT6 blocked the activation of JAK2/STAT3 and inhibited the expression of D1 and Bcl2 in JAK2/STAT3 signaling pathway.

关 键 词：SIRT 胃癌 信号通路 表达水平 

分 类 号：R735.2[医药卫生—肿瘤]