加味逍遥散联合双歧杆菌三联活菌胶囊治疗肠易激综合征的临床疗效及对肠道微生态功能的影响  被引量:38

Curative Effect of Jiawei Xiaoyao San Combined with Bifid-triple Viable Capsule and Its Effects on Clinical Symptoms, Intestinal Microecology Function in Treatment of Patients with Irritable Bowel Syndrome

在线阅读下载全文

作  者:宋小平[1] 陈显韬[1] 敬秀平 SONG Xiao-ping;CHEN Xian-tao;JING Xiu-ping(Department of Anorectal Medicine,People's Hospital of Guang'an City,Guang'an,Sichuan 638000,China)

机构地区:[1]广安市人民医院肛肠科

出  处:《解放军医药杂志》2020年第2期84-87,92,共5页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基  金:四川省卫生和计划生育委员会科研课题(18PJ421)

摘  要:目的分析加味逍遥散联合双歧杆菌三联活菌胶囊治疗对肠易激综合征(IBS)患者临床症状、胃肠功能及肠道微生态功能的影响。方法回顾性分析我院2017年3月-2018年5月就诊收治的76例IBS患者的临床资料。根据治疗药物不同分为观察组与对照组,每组38例。对照组给予双歧杆菌三联活菌胶囊治疗,观察组在对照组基础上联合加味逍遥散。比较2组临床疗效、胃肠功能、肠道微生态功能、用药期间不良反应及复发情况。结果观察组临床总有效率显著高于对照组(P<0.01);治疗后2组乳酸菌、双歧杆菌均较治疗前上升,且观察组高于对照组(P<0.05);治疗后2组肠杆菌、肠球菌、酵母菌较治疗前下降,且观察组低于对照组(P<0.05);2组不良反应发生率比较差异无统计学意义(P>0.05);观察组总复发率显著低于对照组(P<0.01)。结论与单独使用双歧三联活菌胶囊相比,加味逍遥散联合双歧三联活菌胶囊对IBS临床疗效更佳,通过促进肠道正常菌群的生长可抑制其他非正常菌群的生长,从而维持肠道微环境稳定、提高胃肠功能,且长期疗效更佳。Objective To analyze effects of Jiawei Xiaoyao San combined with Bifid-triple Viable capsule on clinical symptoms,gastrointestinal function and intestinal microecology function in patients with irritable bowel syndrome(IBS).Methods Clinical data of 76 patients with IBS admitted during March 2017 and May 2018 was retrospectively analyzed,and the patients were divided into observation group and control group(n=38 in each group)according to different therapeutic drugs.Control group was treated with Bifid-triple Viable capsule,while observation group was supplemented with Jiawei Xiaoyao San.Clinical efficacy,gastrointestinal function,intestinal microecology function and incidence rate of adverse reactions during treatment were compared between two groups.Results The total clinical effective rate in observation group was significantly higher than that in control group(P<0.01).After treatment,levels of lactobacillus and bifidobacterium were significantly increased in two groups,and the levels in observation group were significantly higher than those in control group(P<0.05);levels of enterobacter,Enterococcus and yeast were significantly decreased in two groups,and the levels in observation group were significantly lower than those in control group(P<0.05).There was no significant difference in incidence rate of adverse reactions between two groups(P>0.05).The total recurrence rate in observation group was significantly lower than that in control group(P<0.01).Conclusion Compared with those by use of Bifid-triple Viable capsule alone,Jiawei Xiaoyao San combined with Bifid-triple Viable capsule has better clinical effect in treatment of patients with irritable bowel syndrome.It may inhibit growth of other abnormal flora by promoting growth of intestinal normal flora,maintain stability of intestinal microenvironment and improve gastrointestinal function with better long-term efficacy.

关 键 词:肠易激综合征 加味逍遥 双歧杆菌三联活菌 肠球菌属 酵母菌属 肠杆菌科 

分 类 号:R574.62[医药卫生—消化系统]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象