Treatment and prognosis of hepatic epithelioid hemangioendothelioma based on SEER data analysis from 1973 to 2014  

作　　者：O Kyu Noh Soon Sun Kim Min Jae Yang Sun Gyo Lim Jae Chul Hwang Hyo Jung Cho Jae Youn Cheong Sung Won Cho O Kyu Noh;Soon Sun Kim;Min Jae Yang;Sun Gyo Lim;Jae Chul Hwang;Hyo Jung Cho;Jae Youn Cheong;Sung Won Cho(Department of Radiation Oncology,Ajou University School of Medicine,Suwon,Korea;Department of Biomedical Informatics,Ajou University School of Medicine,Suwon,Korea;Office of Biostatistics,Ajou Research Institute for Innovative Medicine,Ajou University Medical Center,Suwon,Korea;Department of Gastroenterology,Ajou University School of Medicine,Suwon,Korea)

机构地区：[1]Department of Radiation Oncology,Ajou University School of Medicine,Suwon,Korea [2]Department of Biomedical Informatics,Ajou University School of Medicine,Suwon,Korea [3]Office of Biostatistics,Ajou Research Institute for Innovative Medicine,Ajou University Medical Center,Suwon,Korea [4]Department of Gastroenterology,Ajou University School of Medicine,Suwon,Korea

出　　处：《Hepatobiliary & Pancreatic Diseases International》2020年第1期29-35,共7页国际肝胆胰疾病杂志（英文版）

基　　金：supported by the Bio&Medical Tech-nology Development Program of the National Research Foun-dation(NRF);funded by the Korean government(MSIT)(NRF-2018M3A9E8023861);by a grant from the Korean Health R&D Project.Ministry of Health Welfare,Korea(HI18C0531)

摘　　要：Background: Hepatic epithelioid hemangioendothelioma (HEH) is a rare tumor of vascular origin with an unknown etiology, a low incidence, and a variable natural course. We evaluated the management and prognosis of HEH from the Surveillance, Epidemiology and End Results (SEER) program and changes in treatment modalities of HEH over 30 years. Methods: From 1973 to 2014 in the SEER database, we selected patients diagnosed with HEH. We analyzed the clinical characteristics, patterns of management, and clinical outcomes of patients with HEH. Results: We identi ed 79 patients with HEH (median age: 54.0 years;male to female ratio: 1:2.6). The initial extent of disease was local in 22 (27.8%) patients, regional metastasis in 22 (27.8%), distant metas-tasis in 31 (39.2%) and unknown in 4 (5.1%). The median size of primary tumor was 3.85 cm (interquartile range, 2.50 7.93 cm). Among 74 patients with available management data, the most common manage-ment was no treatment (29/74, 39.2%), followed by chemotherapy only (22/74, 29.7%), liver resection-based (13/74, 17.6%), and transplantation-based therapy (6/74, 8.1%). The 5-year cancer-speci c survival rate was 57.8%. Patients who underwent surgical treatment had signi cantly higher survival than those who underwent non-surgical treatment (5-year survival;88% vs. 49%, P=0.019). Multivariate analysis revealed that surgical therapy was the only independent prognostic factor for survival (hazard ratio: 0.20, P=0.040). Conclusions: Resection or liver transplantation is worth considering for treatment of patients with HEH.Background: Hepatic epithelioid hemangioendothelioma(HEH) is a rare tumor of vascular origin with an unknown etiology, a low incidence, and a variable natural course. We evaluated the management and prognosis of HEH from the Surveillance, Epidemiology and End Results(SEER) program and changes in treatment modalities of HEH over 30 years. Methods: From 1973 to 2014 in the SEER database, we selected patients diagnosed with HEH. We analyzed the clinical characteristics, patterns of management, and clinical outcomes of patients with HEH. Results: We identified 79 patients with HEH(median age: 54.0 years; male to female ratio: 1:2.6). The initial extent of disease was local in 22(27.8%) patients, regional metastasis in 22(27.8%), distant metastasis in 31(39.2%) and unknown in 4(5.1%). The median size of primary tumor was 3.85 cm(interquartile range, 2.50–7.93 cm). Among 74 patients with available management data, the most common management was no treatment(29/74, 39.2%), followed by chemotherapy only(22/74, 29.7%), liver resectionbased(13/74, 17.6%), and transplantation-based therapy(6/74, 8.1%). The 5-year cancer-specific survival rate was 57.8%. Patients who underwent surgical treatment had significantly higher survival than those who underwent non-surgical treatment(5-year survival; 88% vs. 49%, P = 0.019). Multivariate analysis revealed that surgical therapy was the only independent prognostic factor for survival(hazard ratio: 0.20, P = 0.040). Conclusions: Resection or liver transplantation is worth considering for treatment of patients with HEH.

关 键 词：HEMANGIOENDOTHELIOMA EPITHELIOID SEER program Liver transplantation HEPATECTOMY Liver neoplasms 

分 类 号：R735.7[医药卫生—肿瘤]