帕金森病患者双眼竞争的研究  

A study of binocular rivalry in patients with Parkinson’s disease

作　　者：杨倩 胡盼盼[2] 方娟[3] 汪凯[2] YANG Qian;HU Pan-Pan;FANG Juan;WANG Kai(Department of Neurology,Nanjing Jiangning Hospital,Nanjing 211100,China)

机构地区：[1]南京市江宁医院神经内科,江苏省南京市211100 [2]安徽医科大学第一附属医院神经内科,安徽省合肥市230022 [3]安徽医科大学第一附属医院急诊内科,安徽省合肥市230032

出　　处：《国际神经病学神经外科学杂志》2019年第6期601-604,共4页Journal of International Neurology and Neurosurgery

基　　金：安徽省重点研究与开发计划项目(1704f0804030);国家重点研发计划(2018YFC1314200)

摘　　要：目的采用双眼竞争范式,探讨帕金森病(PD)患者的双眼竞争交替速率及其可能的神经机制。方法选取临床确诊的原发性PD患者32例(PD组)以及与其人口学资料相匹配的健康对照者32例(HC组)作为研究对象,采用双眼竞争范式进行双眼竞争交替速率的检查。结果PD组双眼竞争交替速率[(0.24±0.07)Hz]较健康对照组[(0.35±0.11)Hz]显著减慢,且二者差异有统计学意义(t=-4.653,P=0.000)。结论PD患者双眼竞争交替速率较健康对照组显著减慢,推测因其额叶-基底节的神经通路损伤从而削弱了知觉的交替变化而影响了双眼竞争交替速率。Objective To investigate the binocular rivalry alternation rate and its possible neural mechanism in patients with Parkinson's disease(PD)using binocular rivalry paradigm.Methods A total of 32 idiopathic PD patients with a confirmed diagnosis were enrolled as PD group,and 32 healthy controls matched for demographic data were enrolled as HC group.To assess the binocular rivalry alternating rate using binocular rivalry test.Results The PD group had a significantly lower binocular rivalry alternation rate than the HC group(0.24±0.07 Hz vs 0.35±0.11 Hz,t=-4.653,P=0.000).Conclusions PD patients have a significantly lower binocular rivalry alternation rate than healthy controls,which may be associated with weakened perceptual alteration caused by frontal lobe-basal ganglia nerve pathway injury.

关 键 词：帕金森病 认知 双眼竞争 

分 类 号：R742.5[医药卫生—神经病学与精神病学]