复生康胶囊联合高强度聚焦超声消融术治疗胃癌肝转移临床研究  

Fushengkang capsules combined high intensity focused ultrasound ablation in the treatment of gastric cancer with liver metastases

作　　者：刘鑫[1] 张锦[1] 袁东红[1] 孟存英[1] 谭玉娥[1] LIU Xin;ZHANG Jin;YUAN Donghong(Department of Gastroenterology,Affiliated Hospital of Yan'an University,Yan’an 716000)

机构地区：[1]延安大学附属医院消化内科

出　　处：《陕西中医》2020年第2期164-167,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：陕西省教育厅自然科学研究项目(2013JK0782)

摘　　要：目的:探讨复生康胶囊联合高强度聚焦超声消融术(HIFUA)治疗不可切除的胃癌肝转移的临床治疗效果。方法:运用随机数字表法将226例不可切除的胃癌肝转移患者分为观察组和对照组,各113例。两组均采用HIFUA进行治疗,观察组另给予复生康胶囊,而对照组则给予安慰剂。治疗前后,检测两组患者免疫功能指标,主要包括IgG、IgA、IgM、CD3^+及CD4^+水平;检测两组患者肿瘤标记物含量,主要包括AFU、GP73、CA242及Frr;检测两组患者肝功能指标,主要包括TBIL、AST、ALP及ALT。治疗后,对两组进行为期3年的随访,分别比较两组患者的1年和3年生存率、PFS和OS。结果:治疗后,观察组IgG、IgA、IgM、CD3^+及CD4^+均显著高于对照组(P<0.05),而AFU、GP73、CA242及Frr含量均显著低于对照组,且TBIL、AST、ALP及ALT含量亦均显著低于对照组(P<0.05)。相较于对照组,观察组患者的1年和3年生存率、PFS及OS均显著升高,且差异具有统计学意义(P<0.05)。结论:复生康胶囊联合HIFUA可有效改善不可切除的胃癌肝转移患者的免疫和肝功能,延长患者的生存时间。Objective:To observe the clinical study of Fushengkang capsules combined high intensity focused ultrasound ablation(HIFUA)in the treatment of unresectable gastric cancer with liver metastases.Methods:A total of 226 patients with unresectable gastric cancer with liver metastases were divided into the observation group and the control group by random number table method,113 cases in each group.The 2 groups were treated by HIFUA,and the observation group and the control group were given Fushengkang capsules and placebo,respectively.Before and after treatment,the immune index(IgG,IgA,IgM,CD3^+ and CD4^+),tumor markers(AFU,GP73,CA242 and Frr),liver function indexs(TBIL,AST,ALP and ALT)of the 2 groups were detected.After the treatment,3 years followup were performed in the 2 groups,and the 1 year survival rate,3 years survival rate,PFS and OS of the 2 groups were compared.Results:After the treatment,the levels of IgG,IgA,IgM,CD3^+ and CD4^+ in the observation group were significantly higher than those in the control group(P<0.05),AFU,GP73,CA242 and Frr were significantly lower than those in the control group(P<0.05),moreover TBIL,AST,ALP and ALT levels were also significantly lower than those in the control group(P<0.05).Compared with the control group,the 1-year and 3-year survival rates,PFS and OS in the observation group were significantly increased,and the difference was statistically significant(P<0.05).Conclusion:Fushengkang capsules combined HIFUA in the treatment of unresectable gastric cancer with liver metastases can effectively promote the immune and liver function,prolong the survival time of patients.

关 键 词：胃癌肝转移 复生康胶囊 高强度聚焦超声消融术 免疫功能 肝功能 生存时间 

分 类 号：R735.2[医药卫生—肿瘤]