石河子市2011年至2018年流产孕妇及不孕夫妻染色体核型分析  

Karyotype analysis of abortion pregnant women and infertile couples in Shihezi from 2011 to 2018

作　　者：刘旻[1] 张玉[1] LIU Min;ZHANG Yu(Department of Reproductive Medicine,the First Affiliated Hospital of Shihezi University.Shihezi,Xinjiang 832008,China)

机构地区：[1]石河子大学医学院第一附属医院生殖医学科

出　　处：《新疆医学》2019年第12期1223-1225,共3页Xinjiang Medical Journal

摘　　要：目的回顾性分析夫妻双方染色体结果,探讨异常染色体核型与孕妇流产及不孕的关系。方法使用R显带方法对2011年3月-2018年2月于石河子大学医学院第一附属医院生殖医学科就诊的968例流产孕妇夫妻及86例不孕夫妻行外周血染色体常规核型分析。结果 (1)经染色体常规核型分析,流产孕妇夫妻异常染色体核型占3.4%,其中男性异常染色体核型占4.5%,明显高于女性,差异有统计学意义(x^2=3.80,P <0.05);(2)不孕夫妻异常染色体核型占5.8%,男性异常染色体核型占7.0%,高于女性,但差异无统计学意义(x^2=0.212,P> 0.05)。结论染色体核型分析可用于协助诊断流产及不孕,对于优生优育及产前筛查亦十分重要。Objective To analyze the chromosome results of both husband and wife retrospectively, to investigate the relationship between abnormal chromosome karyotype and pregnancy abortion and infertility. Methods Chromosome karyotype in the peripheral blood of 968 aborted couples and 86 infertile couples were analyzed in department of reproductive medicine, the First Affiliated Hospital of Shihezi University from March 2011 to February 2018 while using R banding method. Results(1)According to the analysis of chromosome karyotypes, abnormal chromosome karyotypes accounted for 3.4% of the aborted pregnant couples, the abnormal karyotype of men accounted for 4.5%, which was significantly higher than that of women. The difference was statistically significant(x^2 = 3.80,P <0.05).(2)Infertile couples had an abnormal chromosome karyotype of 5.8%, and male abnormal chromosome karyotype accounted for7.0%, which was higher than that of women, However, the difference was not statistically significant(x^2 = 0.212,P > 0.05). Conclusion The karyotype analysis can be used to assist in the diagnosis of abortion and infertility, is also very important for screening and prenatal eugenics.

关 键 词：流产 优生优育 染色体核型分析 

分 类 号：R[医药卫生]