经皮瘤内注射肾上腺素/顺铂对小鼠肝癌的抑制效果  

Inhibitory effect of intraperitoneal injection ofadrenaline/cisplatin on hepatocellular carcinoma in mice

作　　者：江萍 王欣玥 王立峰[2] 刘宝瑞[2] 李茹恬[2] JIANG Ping;WANG Xin-yue;WANG Li-feng;LIU Bao-rui;Li Ru-tian(Department of Oncology,the Second Hospital of Wuhu 241000,China;Department of Oncology,The Comprehensive Cancer Center,Drum-Tower Hospital Affiliated to Medical School of Nanjing University,Nanjing 210008,China)

机构地区：[1]芜湖市第二人民医院肿瘤科,安徽省芜湖市241000 [2]南京大学医学院附属鼓楼医院肿瘤中心,江苏省南京市210008

出　　处：《实用老年医学》2020年第1期24-27,共4页Practical Geriatrics

基　　金：国家自然科学基金(81672398)

摘　　要：目的研究肾上腺素(Adr)和顺铂(DDP)联合用药对小鼠移植性肝癌的作用。方法建立H22肝癌移植瘤模型,当肿瘤长径约6 mm时,将小鼠随机分为4组,每组5只。分组如下:对照组,Adr组,DDP组和Adr+DDP组,观察并比较各组小鼠移植瘤体积大小。结果 Adr组的抑瘤率(inhibition rate,IR)为86. 69%,与对照组比较差异具有统计学意义(P<0. 05)。DDP组和Adr+DDP组的IR分别为84. 11%和93. 26%,2组均对肿瘤有一定的抑制作用,但差异无统计学意义(P=0. 060),Adr和DDP联合用药后对肿瘤的抑制作用有增强趋势(Q=0. 95)。结论 Adr联合DDP可抑制H22肝癌移植瘤的生长。Objective To study the effect of the combination of adrenaline( Adr) and cisplatin( DDP) on transplanted liver cancer in mice. Methods The model of transplanted H22 hepatocellular carcinoma was established. When the length of the tumor was about 6 mm,the mice were randomly divided into four groups with 5 mice in each group. They were control group,Adr group,DDP group and Adr +DDP group. The size of transplanted tumors was observed and compared in each group. Results The inhibition rate( IR) of Adr group was 86. 69%,which was significantly higher than that of control group( P< 0. 05);the IR of DDP group and Adr + DDP group was 84. 11% and 93. 26% repectively. There was no significant difference in IR between Adr + DDP group and DDP group( P>0. 05),but the inhibition of Adr combined with DDP had an increasing trend( Q = 0. 95). Conclusions Adr combined with DDP can inhibit the growth of transplanted H22 hepatocellular carcinoma.

关 键 词：肾上腺素 顺铂 H22肝癌 

分 类 号：R735.7[医药卫生—肿瘤]