甲状腺乳头状癌组织E-cadherin、vimentin的表达及临床意义  

Expression of E-cadherin and vimentin in papillary thyroid carcinoma and its clinical significance

作　　者：唐振宁[1] 李璐[2] 张朝林[1] 刘奇伦[1] TANG Zhen-ning;LI Lu;ZHANG Chao-lin;LIU Qi-lun(Department of Oncology Surgery,General Hospital of Ningxia Medical University,Yinchuan 750004,Ningxia,CHINA;Ningxia Medical University,Yinchuan 750004,Ningxia,CHINA)

机构地区：[1]宁夏医科大学总医院肿瘤外三科,宁夏银川750004 [2]宁夏医科大学,宁夏银川750004

出　　处：《海南医学》2020年第4期425-428,共4页Hainan Medical Journal

基　　金：国家自然科学基金地区项目(编号：81360390);宁夏自然科学基金(编号：NZ13161、NZ17270);宁夏医科大学特殊人才启动项目(编号：XT201327)

摘　　要：目的探讨甲状腺乳头状癌组织中E-钙黏蛋白(E-cadherin)、波形蛋白(vimentin)的表达水平及其临床意义。方法选取2017年1月1日至12月31日在宁夏医科大学总医院住院手术治疗的甲状腺乳头状癌患者63例,结节性甲状腺肿患者23例,以及其中36例甲状腺乳头状癌患者的癌旁组织,采用免疫组化方法检测组织中Ecadherin、vimentin蛋白的表达情况,分析不同甲状腺组织中两者的表达水平及其与甲状腺癌患者临床特征的关系。结果甲状腺乳头状癌组织中E-cadherin的阳性表达率为71.43%,明显高于癌旁组织的19.44%和结节性甲状腺肿组织的17.39%,差异均有统计学意义(P<0.05);甲状腺乳头状癌组织中的vimentin阳性表达率为84.13%,分别与癌旁组织的75.00%和结节性甲状腺肿组织的73.91%比较差异均无统计学意义(P>0.05);E-cadherin、vimentin表达与甲状腺乳头状癌患者的年龄、肿瘤大小及淋巴结转移情况无明显相关(P>0.05)。结论 E-cadherin在甲状腺乳头状癌组织高表达,可能与甲状乳头状癌的发生有关,有助于甲状腺乳头状癌的诊断,vimentin在甲状腺乳头状癌中表达意义尚不明确。Objective To investigate the expression and clinical significance of E-cadherin and vimentin in patients with papillary thyroid cancinoma. Methods Specimens were collected from 63 patients of papillary thyroid cancinoma and 23 patients of thyroid nodular goiter in General Hospital of Ningxia Medical University from January 1, 2017 to December 31, 2017. Paracancerous tissue samples of 36 patients with papillary thyroid carcinoma were also collected. The expression of E-cadherin and vimentin in resected samples were detected by immunohistochemistry. The correlations between the expression of E-cadherin and vimentin with clinicopathologic features were analyzed. Results Immunohistochemical studies demonstrated that E-cadherin expression was significantly higher in papillary thyroid carcinoma(71.43%) than that in adjacent tissue(19.44%) and in thyroid nodular goiter(17.39%), with statistically significant differences(P<0.05). The positive expression rate of vimentin in papillary thyroid carcinoma was 84.13%, which showed no statistically significant difference with 75.00% in adjacent tissues and 73.91% in nodular goiter(P>0.05). E-cadherin and vimentin expression was not significantly correlated with sex, tumor size, or lymph node metastases(P>0.05). Conclusion E-cadherin is related with the occurrence of papillary thyroid carcinoma. The clinical significance of vimentin in papillary thyroid carcinoma is still unclear.

关 键 词：甲状腺乳头状癌 上皮-间质转化 E-钙黏蛋白 波形蛋白 

分 类 号：R736.1[医药卫生—肿瘤]