MRI动态增强成像联合血清CA15-3 CEA对乳腺癌的诊断价值  

Diagnosis the Value of Dynamic Contrast-enhanced MRI Combined with Serum CA15-3 and CEA on Breast Cancer

作　　者：李月梅[1] 仲维秀 杨丽萍[1] LI Yuemei;ZHONG Weixiu;YANG Liping(Shenyang Fifth People's Hospital, Liaoning Shenyang 110023, China)

机构地区：[1]辽宁省沈阳市第五人民医院影像科

出　　处：《河北医学》2020年第2期218-221,共4页Hebei Medicine

基　　金：辽宁省科技攻关计划项目，(编号:2015071352)

摘　　要：目的:探究磁共振成像(MRI)动态增强联合血清CA15-3、癌胚抗原(CEA)在乳腺癌中的诊断价值。方法:选择2018年1月至2019年2月我院收治的80例乳腺癌患者纳入乳腺癌组,另择同期收治的50例乳腺良性肿瘤患者纳入良性组,所有患者均行MRI动态增强扫描,检测血清CA15-3、CEA水平,比较各组血清学指标差异并分析指标单独或联合用于乳腺癌诊断的价值。结果:乳腺恶性病灶MRI表现为与周围组织分界不清,可见边缘不规则或伴有毛刺形成,强化多不均匀;乳腺良性病灶表现为与周围组织边界清晰、边缘光滑的肿块,呈类圆形或分叶状,多数病灶强化均匀;乳腺癌组患者CA15-3、CEA指标水平显著高于良性组(P<0.05);MRI及血清CA15-3、CEA单独诊断时,CEA的诊断敏感度、准确度最低,MRI诊断敏感度、准确度最高;MRI联合CA15-3、CEA诊断敏感度显著高于MRI、血清CA15-3、CEA单独诊断(P<0.05),特异度低于其他三种方法单独诊断。结论:MRI动态增强扫描联合血清CA15-3、CEA可提高乳腺癌诊断灵敏度,对乳腺癌早期诊断具有较高的应用价值。Objective:To explore the diagnostic value of dynamic contrast-enhanced magnetic resonance imaging(MRI)combined with serum CA15-3 and carcinoembryonic antigen(CEA)for breast cancer.Methods:80 patients with breast cancer admitted to the hospital from January 2018 to February 2019 were included in the breast cancer group.50 patients with benign breast tumors were selected and included in the benign group,respectively.All patients underwent dynamic contrast-enhanced MRI.Serum CA15-3 and CEA levels were detected.The differences in serological indicators among groups and the value of the indicators alone or combined diagnosis for breast cancer were analyzed.Results:MRI findings of malignant breast lesions showed unclear boundaries with surrounding tissues,irregular margins or burrs,and inhomogeneous enhancement.Findings of benign breast lesions showed masses with clear boundaries with surrounding tissues and smooth edge,round or lobulated shape,and homogeneous enhancement of most lesions.Levels of CA15-3 and CEA in the breast cancer group were significantly higher than those in the benign group(P<0.05).For alone diagnosis,the diagnostic sensitivity and accuracy of CEA were the lowest while diagnostic sensitivity and accuracy of MRI were the highest.The diagnostic sensitivity of MRI combined with CA15-3 and CEA was significantly higher than that of MRI,serum CA15-3 or CEA alone(P<0.05),while the specificity was lower than the other three methods.Conclusion:Dynamic contrast-enhanced MRI combined with serum CA15-3 and CEA can improve the diagnostic sensitivity of breast cancer,which is of value for the early diagnosis of breast cancer.

关 键 词：磁共振成像 动态增强 乳腺癌 

分 类 号：R73[医药卫生—肿瘤]