阿立哌唑联合奥氮平对老年精神分裂症患者临床疗效糖脂代谢的影响  

Study on the Effect of Aripiprazole Combined with Olanzapine on Clinical Efficacy Glucose and Lipid Metabolism of Elderly Schizophrenic Patients

作　　者：陈明菊[1] 米莉 罗明[1] 杨金华[1] CHEN Mingju(Panzhihua Third People's Hospital, Sichuan Panzhihua 617000, China)

机构地区：[1]四川省攀枝花市第三人民医院,四川攀枝花617000 [2]四川省成都市第四人民医院精神科,四川成都610000

出　　处：《河北医学》2020年第2期248-252,共5页Hebei Medicine

基　　金：四川省医学会科研课题，(编号:S18006)

摘　　要：目的:阿立哌唑联合奥氮平对老年精神分裂症患者临床疗效、糖脂代谢以的影响。方法:选取2016年1月至2018年2月我院收治120例精神不分裂者为研究对象,采用随机数字表法分为对照组60例和观察组60例。进行为期8周的治疗。两组患者均给与常规的精神病药物治疗,对照组在基础药物治疗上给与阿立哌唑进行治疗,开始剂量定为10~20mg,根据患者的实际病情来调整用药剂量。观察组则是在对照组治疗基础上联合奥氮平进行治疗开始剂量定为10~20mg。治疗时间为8周。结果:两组患者治疗后临床总有效率比较,对照组的临床总有效率为56.66%观察组的临床总有效率为96.66%,对照组临床总有效率明显低于观察组(P<0.05)。两组患者治疗8周后血脂、血糖比较,治疗后观察组组低于对照(P<0.05)。治疗前两组患者心理功能、物质生活计算结果差异没有统计学意义(P>0.05),治疗后两组患者生活质量均有所改善,但观察组治疗前后的生活质量改善程度明显大于对照组(P<0.05)。结论:阿立哌唑联合奥氮平对老年精神分裂症患者临床疗效显著,对改善糖脂代谢有明显作用,可提高精神分裂症患者生活质量水平。Objective:To study the effect of aripiprazole combined with olanzapine on the clinical efficacy,glucose and lipid metabolism of elderly schizophrenic patients.Methods:120 patients with schizophrenia admitted to our hospital from January 2016 to February 2018 were selected as the research objects,and divided into the control group(60 cases)and the observation group(60 cases)according to the random number table.They were treated for eight weeks.Patients in both groups were given conventional psychiatric medication,while those in the control group were supplemented with aripiprazole on the basis of conventional treatment.The initial dose was set at 10~20 mg,and the dosage was adjusted according to the actual condition of patients.The observation group was supplemented with olanzapine on the basis of treatment of the control group and the starting dose was set at 10~20 mg.The duration of treatment was 8 weeks.Results:The total clinical effective rate of the two groups after treatment was compared,the total clinical effective rate of the control group was 56.66%,the total clinical effective rate of the observation group was 96.66%,the total clinical effective rate of the control group was significantly lower than that of the observation group,the difference was statistically significant(P<0.05).After 8 weeks of treatment,blood lipid and blood glucose between the two groups were compared,and the observation group after treatment was lower than the control group.There was no significant difference in the calculation result of psychological function and material life between the two groups before treatment(P<0.05).After treatment,the quality of life of the two groups improved,but the improvement in quality of life before and after treatment in the observation group was significantly greater than that in the control group(P<0.05).Conclusion:Aripiprazole combined with olanzapine has a significant clinical effect on elderly patients with schizophrenia,has a significant effect on improving glucose and lipid metabolism,and ca

关 键 词：阿立哌唑 奥氮平 老年精神分裂症 糖脂代谢 

分 类 号：R74[医药卫生—神经病学与精神病学]