8q24 rs1447295基因多态性与不同族群前列腺癌易感性的Meta分析  

Meta-analysis of the association between 8q24 rs1447295 gene polymorphism and prostate cancer susceptibility in different ethnic groups

作　　者：毛顿 谭政 李曾 杨盛柯 钟磊 廖洪 肖英明 吴毅 段丹丽[2] MAO Dun;TAN Zheng;LI Zeng;YANG Sheng-ke;ZHONG Lei;LIAO Hong;XIAO Ying-ming;WU Yi;DUAN Dan-li(Department of Urology,Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610041;Sichuan Cancer Hospital&Institute,Chengdu 610041,China)

机构地区：[1]四川省肿瘤医院研究所,四川省癌症防治中心,电子科技大学医学院泌尿外科,四川成都610041 [2]四川省肿瘤医院·研究所,四川成都610041

出　　处：《现代泌尿外科杂志》2020年第2期162-173,共12页Journal of Modern Urology

基　　金：四川科技厅重大科技项目（No.2017SZ0102）

摘　　要：目的通过Meta分析系统评价8q24染色体rs1447295基因多态性与不同族群前列腺癌(prostate cancer,PCa)患病风险的相关性。方法检索万方、中国知网、PubMed、Science Direct、Web of Science、Wiley Online Library和中国生物医学文献数据库中涉及8q24 rs1447295基因多态性和PCa易感性的病例-对照研究。2位独立研究者按标准筛选文献,运用Cochrane工具及Stata 15.0软件行Meta分析,计算OR值、95%CI并进行偏倚风险评价。结果最终纳入相关文献36篇,涉及研究41项,包含25715例PCa患者和27018例健康对照者。结果显示,在5类基因模型中,等位基因模型、显性遗传模型、隐性遗传模型、纯合子遗传模型与杂合子基因模型显示8q24 rs1447295基因多态性均与PCa易感性之间存在显著相关性,差异有统计学意义(P<0.05)。进一步亚组分析显示,在高加索人种和亚洲人种中,8q24 rs1447295基因多态性与PCa易感性相关,且差异均有统计学意义(P<0.05),在非裔和拉美裔群体中未显示有统计学关联。结论8q24染色体rs1447295基因多态性与PCa患病风险有关,该相关性在高加索人种和亚洲人种中较为显著,在非裔和拉美裔群体关联性无显著差异。Objective To investigate the association between 8q24 rs1447295 gene polymorphism and risk of prostate cancer(PCa)in different ethnic groups.Methods The case-control studies on the association between 8q24 rs1447295 gene polymorphism and PCa susceptibility were searched in WANFANG,CNKI,PubMed,Science Direct,Web of Science,Wiley Online Library and Chinese Biomedical Literature Database.The data were extracted independently by two researchers based on the inclusion and exclusion criteria.A Meta-analysis was conducted with Cochrane tools and Stata 15.0 software.The odds ratio(OR),95%confidence interval(95%CI)and risk of bias were calculated.Results A total of 36 literatures including 41 studies were collected,involving 25715 PCa cases and 27018 healthy controls.A significant association was found between PCa and 8q24 rs1447295 gene polymorphism in allele model,dominant model,recessive model,homozygote model and heterozygote model(P<0.05).Ethnicity-based subgroup analyses showed that 8q24 rs1447295 gene polymorphism was significantly associated with PCa susceptibility in Caucasian and Asian populations(P<0.05),but not in African and Latino populations.Conclusion The 8q24 rs1447295 gene polymorphism is associated with prostate cancer susceptibility,especially in Caucasian and Asian populations,but not in African and Latino populations.

关 键 词：8q24 rs1447295基因多态性 前列腺癌 易感性 不同种族 荟萃分析 

分 类 号：R737.25[医药卫生—肿瘤]