机构地区:[1]中国医科大学附属第一医院超声科
出 处:《中国临床医学影像杂志》2020年第1期24-29,共6页Journal of China Clinic Medical Imaging
摘 要:目的:探讨S-Detect应用于乳腺包块中敏感性、特异性、符合率的影响因素。分析S-Detect与超声医师联合诊断的诊断价值,及与病理诊断的一致性。方法:回顾性分析经病理证实且同时应用S-Detect技术诊断的453例乳腺肿物患者的相关资料,根据S-Detect的影响因素分组,采用卡方检验计算并比较S-Detect诊断的敏感性、特异性、符合率。采用Logistic回归分析方法研究影响因素与病理诊断良恶性的关系。由一个超声医师进行乳腺超声检查与S-Detect检查,由另一个超声医师对留存图像进行分析根据美国放射学会BI-RADS分级对包块进行分级,再联合S-Detect做出联合诊断。计算并比较S-Detect、超声医师、联合诊断与病理诊断结果的ROC曲线下面积及一致性。结果:453位女性患者,共581个病灶,病理诊断良性病灶411个,恶性病灶170个。S-Detect诊断导管内乳头状瘤及4 cm>病灶≥2 cm的良性病灶误诊率较高,且有统计学差异。S-Detect诊断的特异性较高(>80.00%)。S-Detect在患者年龄、乳腺包块所在象限及乳腺包块所在深度分组中敏感性、特异性在组内均无统计学差异。病理Logistic回归得出3个有意义的危险因素(年龄、S-Detect、乳腺包块最大径),P<0.05。以病理结果为金标准,SDetect的诊断结果 ROC曲线下面积为0.78,Kappa=0.45,超声医师的诊断结果ROC曲线下面积为0.78,Kappa=0.57,超声医师联合S-Detect(初次联合诊断)的诊断结果 ROC曲线下面积为0.84,Kappa=0.65,超声医师联合S-Detect并参考年龄、最大径及S-Detect的影响因素(再次联合诊断)的诊断结果 ROC曲线下面积为0.89,Kappa=0.76,P<0.05。结论:S-Detect诊断的特异性较高,诊断浸润性导管癌的符合率较高,诊断导管内乳头状瘤符合率较低,4 cm>病灶≥2 cm的良性病灶漏诊率较高。S-Detect应用于乳腺包块的诊断可以提高超声医师诊断的诊断价值及与病理诊断的一致性。Objective: To investigate the influence factors of the sensitivity, specificity and accuracy of S-Detect. To analyze the diagnostic value and the agreement of the combined diagnosis with a radiologist specializing in breast lesions. Methods: Grouped by the influence factors of S-Detect, chi-square test was used to calculate and compare the sensitivity, specificity and accuracy of S-Detect. Logistic regression was used to analyze the relationship between various factors and the results of pathological diagnosis that was benign or malignant. Breast ultrasound and S-Detect were operated by a radiologist specializing in breast imaging. The other radiologist analyzed the ultrasonographic images of the breast masses according to the American College of Radiology Breast Imaging Reporting and Data System(BI-RADS), and then made the combined diagnosis on the results of S-Detect. The area under the receiver operating characteristic(ROC) curve and the agreement among the SDetect, radiologist, combined diagnosis were calculated and compared. Results: In all the 581 lesions, pathological diagnosis showed 411 benign lesions and 170 malignant lesions. The false positive rate of S-Detect in intraductal papilloma and which was between 2 cm to 4 cm was higher(P<0.05). The specificity of S-Detect was all higher than 80.00%. The sensitivity and specificity of S-Detect were not statistically significant in the groups of the age, the location of the lesions and the depth of the lesion. Three significant risk factors(age, S-Detect, the most largest size of lesions) for pathology were analyzed with logistic regression(P<0.05). Moderate agreement was seen in final assessments made by S-Detect, radiologist and combined diagnosis(the primary combined diagnosis)(Kappa =0.45, 0.571 and 0.65, respectively) with pathological results as the gold standard.Good agreement was seen in final assessments made by combined diagnosis in consideration of age and the largest size of lesions(the recombined diagnosis)(Kappa=0.76). The area under ROC curve w
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