胰腺癌肿瘤微环境的研究进展  

Research progress in tumor microenvironment of pancreatic cancer

作　　者：王超[1] 宁克 胡欢欢 袁春辉 殷香保[1] Wang Chao;Ning Ke;Hu Huanhuan;Yuan Chunhui;Yin Xiangbao(Department of Hepatopancreatobiliary Surgery,the Second Affiliated Hospital,Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第二附属医院肝胆胰外科,南昌330006

出　　处：《中华消化外科杂志》2020年第1期109-112,共4页Chinese Journal of Digestive Surgery

基　　金：国家自然科学基金资助项目(81760439);江西省自然科学基金项目(20181BAB205049)。

摘　　要：胰腺癌是一种预后极差的恶性肿瘤。一方面,由于缺少特异性标志物、早期症状不明显,胰腺癌的治疗窗口期较小,一经确诊通常已发展至晚期。另一方面,胰腺解剖位置特殊,手术操作难度大,术后肿瘤复发率高,手术治疗仅适于少数早期患者。胰腺癌肿瘤微环境的特点包括基质丰富、缺氧、血供不足和高度免疫抑制等,传统放化疗很难发挥治疗作用。因此,针对胰腺癌肿瘤微环境寻找新的治疗靶点是极有潜力的研究方向。笔者就胰腺癌肿瘤微环境近年的研究进展进行综述,旨在为胰腺癌的进一步研究与治疗提供参考。Pancreatic cancer is an aggressive malignant tumor with poor prognosis.On the one hand,it has a narrow therapeutic window due to the lack of specific markers and obvious clinical symptoms.Once diagnosed,it has often developed to an advanced stage.On the other hand,located in a vital region of the body,pancreatic operation is difficult and the postoperative recurrence rate is high.Therefore,surgical treatment is only sui-table for a small number of early patients.Pancreatic cancer has a tumor microenvironment with the characteristic of dense stroma,hypoxia,paucity of blood vessels and highly immunosuppression.It is often insensitive to traditional radiation and chemotherapy.Therefore,strategies targeting on tumor microenvironment have a potential prospect.This article reviews the research progress in tumor microenvironment of pancreatic cancer,in order to provide the references in the further research and treatment of pancreatic cancer.

关 键 词：胰腺肿瘤 肿瘤微环境 胰腺星状细胞 免疫抑制 基质屏障 

分 类 号：R735.9[医药卫生—肿瘤]