富生长因子血浆引导组织再生术治疗牙周骨内缺损的临床效果  

The Clinical Effect of Growth Factor Rich Plasma Guided Tissue Regeneration for the Treatment of Periodontal Bone Defects

作　　者：孙旸[1] 高承志[1] Sun Yang;Gao Chengzhi(People's Hospital of Peking University,Beijing,100044)

机构地区：[1]北京大学人民医院

出　　处：《基因组学与应用生物学》2019年第12期5689-5694,共6页Genomics and Applied Biology

摘　　要：牙周再生定义为完全恢复失去的牙周组织及其原始结构和功能。富生长因子血浆(PRGF)是促进丢失的牙周组织恢复的生长因子浓缩悬浮液。为了评估PRGF联合引导组织再生(GTR)治疗术与仅GTR治疗术在治疗慢性牙周炎患者牙周骨内缺损的临床效果,42处牙周骨缺损的慢性牙周炎患者(n=14)随机分配到试验组(PRGF+GTR)和对照组(仅GTR)。临床和射线检测结果评估术前和术后6个月的:牙龈指数(GI)、牙周探诊深度(PD)、临床附着水平(CAL)、缺损深度(Radiological defect depth)以及骨充填(Bone fill)。术前和术后6个月的临床参数显示对照组平均牙周探诊深度降低(3.37±1.62) mm (p<0.001),试验组平均牙周探诊深度降低(4.13±1.59) mm (p<0.001)。对照组(5.42±1.99)和试验组(5.99±1.77)临床附着水平平均变化以及牙龈指数平均变化(对照组(1.89±0.32)和试验组(1.68±0.58))有显著性差异(p<0.001)。比较各组间临床参数,无统计学显著差异。对照组和试验组平均骨缺损充填为(1.06±0.81)和(1.0±0.97),该差异无统计学意义。6个月的随访中,PRGF+GTR联合治疗以及单独GTR治疗对慢性牙周炎患者的临床附着水平和缺损深度有显著改善作用。PRGF+GTR联合治疗中,PRGF对慢性牙周炎患者的临床附着水平和缺损深度无累加效应。Periodontal regeneration is defined as complete restoration of lost periodontal tissue and its original structure and function.Growth factor rich plasma(PRGF) is a concentrated suspension of growth factors that promotes recovery of lost periodontal tissue.In order to evaluate the clinical effects of PRGF combined with guided tissue regeneration(GTR) and GTR alone for the treatment of periodontal bone defects in chronic periodontitis patients,Forty-two periodontal bone defects in chronic periodontitis patients(n=14) were randomly assigned to the experimental group(PRGF+GTR) and the control group(GTR).The gingival index(GI),periodontal probing depth(PD),clinical attachment level(CAL),radial defect depth,and bone filling(Bone Fill) of preoperative and postoperative 6 months were evaluated by Clinical and radiographic evaluation.Preoperative and postoperative 6-month clinical parameters showed that the mean periodontal probing depth in the control group decreased by(3.37±1.62) mm(p<0.001),and the average periodontal probing depth in the experimental group decreased by(4.13±1.59) mm(p<0.001).There was a significant difference between the control group(5.42±1.99) and the experimental group(5.99±1.77) in the mean clinical attachment level and the average change in the gingival index(control group(1.89±0.32) and test group(1.68±0.58))(p<0.001).Comparing the clinical parameters between groups,there was no statistically significant difference.The mean bone defect filling in the control group and the experimental group was(1.06±0.81) and(1.0±0.97),but the difference was not statistically significant.During the 6-month follow-up,PRGF+GTR combination therapy and GTR alone in the treatment both significantly improved the clinical attachment and defect depth in patients with chronic periodontitis.In the PRGF+GTR combination therapy,there was no cumulative effect of PRGF on the clinical attachment level and defect depth in patients with chronic periodontitis.

关 键 词：临床试验 引导组织再生 牙周再生 牙周炎 牙周手术 

分 类 号：R781.4[医药卫生—口腔医学]