丙戊酸钠单药治疗儿童癫痫对血脂水平影响的Meta分析  

Meta-Analysis of Effects of Sodium Valproate Monotherapy on Serum Lipid Levels in Children with Epilepsy

作　　者：张瑶 申良荣[2] 房夏玲[2] Zhang Yao;Shen Liangrong;Fang Xialing(Qingdao Binhai University,Shandong Qingdao 266000,China;The First Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710061,China)

机构地区：[1]青岛滨海学院,山东青岛266000 [2]西安交通大学第一附属医院,陕西西安710061

出　　处：《儿科药学杂志》2020年第1期14-18,共5页Journal of Pediatric Pharmacy

摘　　要：目的:系统评价丙戊酸钠单药治疗儿童癫痫对血脂水平的影响。方法:系统检索中国知网、万方数据库、PubMed、the Cochrane Library、Embase数据库中的病例对照研究、队列研究及横断面研究,由2名研究人员独立按照纳入标准及排除标准筛选文献,提取资料和评价文献质量后,应用RevMan 5.3软件进行Meta分析。结果:20篇文献纳入Meta分析,均为病例对照研究,累计病例组586例,对照组1155例。Meta分析结果显示,两组总胆固醇[SMD=0.24,95%CI(-0.11,0.58)]、甘油三酯[SMD=0.28,95%CI(-0.06,0.62)]、高密度脂蛋白[SMD=0.12,95%CI(-0.16,0.39)]、低密度脂蛋白[SMD=0,95%CI(-0.31,0.32)]比较,差异均无统计学意义(P均>0.05)。结论:基于目前的证据可认为,丙戊酸钠单药治疗对癫痫患儿的血脂水平无影响,但鉴于纳入文献质量较低及样本量较少的问题,本研究结果仍需大样本、高质量文献进一步验证。Objective:To systematically evaluate the sodium valproate monotherapy on serum lipid levels in children with epilepsy.Methods:CNKI,Wanfang database,PubMed,the Cochrane Library and Embase were retrieved to collect the case-control study,cohort study and cross-sectional study.Literature were screened independently by two researchers based on inclusion and exclusion criteria.After extracting the data and evaluating the quality of the literature,the RevMan 5.3 software was used for Meta-analysis.Results:Twenty literature were included in the Meta-analysis,all of which were case-control studies,with a total of 586 cases in the case group and 1,155 cases in the control group.Meta-analysis showed that there were no statistically significant differences between two groups in total cholesterol[SMD=0.24,95%CI(-0.11,0.58)],triglycerides[SMD=0.28,95%CI(-0.06,0.62)],high-density lipoprotein[SMD=0.12,95%CI(-0.16,0.39)]and low-density lipoprotein[SMD=0,95%CI(-0.31,0.32)](P>0.05).Conclusion:Based on current evidence,it can be concluded that sodium valproate monotherapy has no effect on serum lipid levels in children with epilepsy.However,in view of the low quality of the included literature and the small sample size,the results of this study need to be further verified by large samples and high-quality literature.

关 键 词：癫痫 丙戊酸钠 血脂 儿童 META分析 

分 类 号：R748[医药卫生—神经病学与精神病学]