非酒精性脂肪性肝炎的磁共振成像研究进展  

Research progress of magnetic resonance imaging for diagnosis of nonalcoholic steatohepatitis

作　　者：胡富碧[1] 杨茹[1] HU Fubi;YANG Ru(Department of Radiology,The First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,P.R.China)

机构地区：[1]成都医学院第一附属医院放射科

出　　处：《中国普外基础与临床杂志》2020年第2期209-215,共7页Chinese Journal of Bases and Clinics In General Surgery

基　　金：成都医学院科研创新团队项目(项目编号:CYTD19-03)

摘　　要：目的总结各种磁共振技术在非酒精性脂肪性肝炎(NASH)中的研究进展。方法查阅国内外相关文献,综述各种磁共振技术在NASH诊断中的现状与进展,并总结它们各自的优缺点和存在的问题。结果各种磁共振成像技术包括磁共振弹性成像、钆塞酸二钠对比增强磁共振成像、磁共振扩散加权成像、磁共振脂铁定量成像等已经广泛应用于NASH的研究,并表现出一定的诊断价值。然而,尚无可靠的磁共振技术被推荐用于NASH的临床诊断。结论磁共振成像是无创性评价NASH的重要方法,未来迫切需要进一步深入研究构建由血清学指标与影像生物标志物组成的NASH无创性诊断模型,从而减少不必要的肝活检。Objective To summarize the research progress of magnetic resonance imaging(MRI) for diagnosis of nonalcoholic steatohepatitis(NASH). Method Relevant literatures at home and abroad were collected to make an review, then summarized the research status and progress of MRI for diagnosis of NASH. Their advantages and disadvantages were summarized. Results A variety of MRI techniques, including MR elastography, gadoliniumethoxybenzyldiethylenetriaminepentaacetic acid(Gd-EOB-DTPA) enhanced MRI, diffusion-weighted MR imaging, and quantitative MR imaging of fat and iron, had been widely used in diagnosing NASH and shown to have some value.However, there were currently no effective MRI techniques recommended for diagnosing NASH. Conclusions MRI plays an important role in noninvasive assessment of NASH. Future studies are needed to investigate more efficient noninvasive biomarkers and models consisting of imaging and non-imaging biomarkers for diagnosing NASH, to reduce unnecessary biopsies.

关 键 词：非酒精性脂肪性肝炎 磁共振成像 影像生物标志物 无创性评价 综述 

分 类 号：R575.1[医药卫生—消化系统] R445.2[医药卫生—内科学]