地西他滨联合CHG方案治疗中高危老年急性髓系白血病的临床效果  

Clinical effect of Decitabine combined with CHG regimen in the treatment of medium or high risk elderly acute myeloid leukemia

作　　者：闫朝奇 冷青[1] 季征[1] 吴音[1] 张丽君[2] YAN Chao-qi;LENG Qing;JI Zheng;WU Yin;ZHANG Li-jun(Department of Hematology,Central Hospital of Anshan City,Liaoning Province,Anshan114000,China;Department of Hematology,the First Affiliated Hospital of China Medical University,Liaoning Province,Shenyang110000,China)

机构地区：[1]辽宁省鞍山市中心医院血液科,辽宁鞍山114000 [2]中国医科大学附属第一医院血液科,辽宁沈阳110000

出　　处：《中国当代医药》2020年第3期125-128,共4页China Modern Medicine

基　　金：辽宁省创新诊疗装备区域应用示范项目（2017Y FC0114200）

摘　　要：目的探讨地西他滨联合CHG方案治疗中高危老年急性髓系白血病(AML)的临床效果。方法纳入2016年6月~2019年6月鞍山市中心医院收治的60例初诊为急性中高危AML老年患者作为研究对象,根据随机数字表法将其分为地西他滨联合CHG方案治疗组(32例)与单药治疗组(28例)。地西他滨联合CHG方案治疗组采用地西他滨20 mg/(m2·d)联合CHG方案化疗,单药治疗组仅采用地西他滨单药治疗,剂量同地西他滨联合CHG方案治疗组。比较两组患者经1个疗程治疗后的临床效果、血象恢复时间及不良反应发生情况。结果两组患者的治疗总有效率比较,差异无统计学意义(P>0.05)。两组患者血小板及白细胞的恢复时间比较,差异无统计学意义(P>0.05)。地西他滨联合CHG方案治疗组患者的感染发生率高于单药治疗组,差异有统计学意义(P<0.05),而两组患者的肝功损害、恶心呕吐、便秘、疲劳发生率及死亡率比较,差异无统计学意义(P>0.05)。结论完成1个疗程的治疗后,地西他滨联合CHG方案治疗组的治疗总有效率并无提高,但感染的发生率可能更大。Objective To investigate the clinical effect of Decitabine combined with CHG regimen in the treatment of medium or high risk elderly acute myeloid leukemia(AML).Methods From June 2016 to June 2019,60 elderly patients with acute moderate to high risk AML admitted to Central Hospital of Anshan city were included as the research objects,and divided into Decitabine combined CHG regimen treatment group(32 cases)and monotherapy group(28 cases)according to the random number table method.The Decitabine combined with CHG regimen treatment group was treated with Decitabine 20 mg/(m2·d)combined with CHG regimen chemotherapy,while the monotherapy group was only treated with Decitabine single drug,and the dosage was the same as that of the Decitabine combined with CHG regimen treatment group.The clinical effects,blood picture recovery time and adverse reactions of the two groups after one course of treatment were compared.Results There was no significant difference in the total effective rate between the two groups(P>0.05).There were no significant difference in recovery time of platelets and leukocytes between the two groups(P>0.05).The incidence of infection in patients of the Decitabine combined with CHG regimen treatment group was higher than that in patients of the monotherapy group,the difference was statistically significant(P<0.05),while there were no statistically significant difference in liver function damage,nausea,vomiting,constipation,fatigue incidence and mortality between the two groups(P>0.05).Conclusion After completing one course of treatment,the total effective rate of Decitabine combined with CHG regimen treatment group did not improve,but the incidence of infection may be greater.

关 键 词：地西他滨 急性髓系白血病 去甲基化 老年人 

分 类 号：R733.71[医药卫生—肿瘤]