溶血磷脂酸与不同类型急性脑梗死和颈动脉粥样硬化斑块的相关性  

Correlation Between Lysophosphatidic Acid and Different Types of Acute Cerebral Infarction and Carotid Atherosclerotic Plaques

作　　者：苏建 刘美香 刘辉 蒋超[3] SU Jian;LIU Mei-xiang;LIU Hui;JIANG Chao(Department of Neurology,Zhengzhou Second Hospital,Zhengzhou 450000,China;Department of Neurology,Kaifeng Central Hospital,Kaifeng 475000,China;Department of Neurology,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州市第二人民医院神经内科,河南郑州450000 [2]开封市中心医院神经内科,河南开封475000 [3]郑州大学第五附属医院神经内科,河南郑州450000

出　　处：《河南医学研究》2020年第3期390-393,共4页Henan Medical Research

基　　金：国家自然科学基金资助项目(81671165)

摘　　要：目的研究溶血磷脂酸(LPA)与不同类型急性脑梗死及颈动脉粥样硬化(CAS)斑块之间的关系。方法选取2016年10月至2018年6月郑州市第二人民医院收治的发病48 h内的218例急性脑梗死患者为观察组,据发病次数分为首发性、再发性脑梗死组;据症状是否进展分为进展性、稳定性脑梗死组,据临床神经功能损害程度分为轻型、中型、重型脑梗死组,据颈动脉超声检查分为无斑块组、稳定性斑块组、不稳定性斑块组。选择已排除脑血管病的80例健康体检者作为对照组。比较各组LPA水平及斑块检出情况。结果观察组LPA水平、CAS斑块的总体检出率及不稳定性斑块的检出率均高于对照组,差异有统计学意义(均P<0.05);不稳定性斑块组LPA水平高于稳定性斑块组和无斑块组,差异有统计学意义(均P<0.05)。再发性脑梗死组LPA水平高于首发性脑梗死组,差异有统计学意义(P<0.05)。进展性脑梗死组LPA水平高于稳定性脑梗死组,差异有统计学意义(P<0.05)。中、重型脑梗死组LPA水平均高于轻型脑梗死组,重型脑梗死组LPA水平高于中型脑梗死组,差异有统计学意义(均P<0.05)。结论监测LPA水平有助于评估脑梗死的发生以及严重程度,同时可指导抗血小板聚集、抗炎、抗氧化、稳定粥样斑块、保护血管内皮类药物的临床应用,在缺血性脑血管病预防和治疗中起重要作用。Objective To investigate the relationship between lysophosphatidic acid(LPA)and different types of acute cerebral infarction and carotid atherosclerotic plaques.Methods All 218 patients with acute cerebral infarction within 48 hours were selected as observation group in Zhengzhou Second Hospital from October 2016 to June 2018.Observation group was divided into first-onset cerebral infarction group and recurrent cerebral infarction group according to the incidence times,and divided into progressive cerebral infarction group and stable cerebral infarction group according to whether the symptoms progress or not,and divided into light,medium and heavy cerebral infarction groups on the degree of clinical neurological damage,and divided into no-plaque group,stable plaque group and unstable plague group according to the results of carotid ultrasound.Meanwhile 80 well-matched healthy people without cerebrovascular disease were determined as control group.The LPA level and plaque detection in each group were compared.Results The level of LPA,the overall detection rate of CAS plaque and the detection rate of unstable plaque in observation group were higher than those in control group,and the differences were statistically significant(both P<0.05).The level of LPA in unstable plaque group was higher than those in stable plaque group and no-plaque group,and the differences were statistically significant(both P<0.05).The level of LPA in recurrent cerebral infarction group was higher than that in first-onset cerebral infarction group,and the difference was statistically significant(P<0.05).The level of LPA in progressive cerebral infarction group was higher than that in stable cerebral infarction group,and the difference was statistically significant(P<0.05).The levels of LPA in medium and severe cerebral infarction group were higher than that in light cerebral infarction group,and the level of LPA in severe cerebral infarction group was higher than that in medium cerebral infarction group,and the differences were statisticall

关 键 词：急性脑梗死 溶血磷脂酸 颈动脉粥样硬化斑块 

分 类 号：R741[医药卫生—神经病学与精神病学]